Short-course 2d-radiotherapy in the palliative treatment of oesophageal cancer in a developing country: a phase ii study (sharon project)

A phase II trial was proposed to define the efficacy of a short-course radiotherapy for symptomatic palliation of metastatic or locally advanced oesophageal cancer in a low resourced setting where only a 2D-radiotherapy technique was available. Results showed that the delivery of a total dose of 12 Gy in 4 fractions, twice-a-day, over 2 days, ≥ 8 hours apart, was tolerated and effective for the symptomatic palliation of metastatic or locally advanced oesophageal malignancies.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research

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The aim of this review was to examine efficacy of palliative interventional radiotherapy (IRT) in esophageal cancer compared with other treatment in terms of dysphagia-free survival (DyFS) and safety.
Source: Brachytherapy - Category: Cancer & Oncology Authors: Tags: Review Article Source Type: research
This study aimed to evaluate the value of palliative resection or radiation of primary tumor for metastatic esophageal cancer using the Surveillance, Epidemiology, and End Results database. Additionally, we constructed prognostic nomograms for both preoperative and postoperative risk factors. We found that palliative resection or radiation could improve the survival of such patients, across both squamous cell carcinoma and adenocarcinoma. AbstractPurposeWe aimed to explore the value of palliative resection or radiation of primary tumor for metastatic esophageal cancer (EC) patients.MethodsSurveillance, Epidemiology, and En...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Patients with locally advanced and metastatic esophageal cancer are usually affected by cancer-related symptoms, which worsen their performance status and quality of life. The aim of this study was to determine the efficacy of short-course accelerated radiation therapy for symptomatic palliation in a low resourced setting where only a 2-dimensional radiation therapy (RT) technique was available.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Clinical Investigation Source Type: research
This study aimed to evaluate the value of palliative resection or radiation of primary tumor for metastatic esophageal cancer using the Surveillance, Epidemiology, and End Results database. Additionally, we constructed prognostic nomograms for both preoperative and postoperative risk factors. We found that palliative resection or radiation could improve the survival of such patients, across both squamous cell carcinoma and adenocarcinoma. AbstractPurposeWe aimed to explore the value of palliative resection or radiation of primary tumor for metastatic esophageal cancer (EC) patients.MethodsSurveillance, Epidemiology, and En...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
AbstractPurposeTo investigate the effect of prior chemotherapy on self-expanding metal stent (SEMS)-related complications in patients with locally advanced primary esophageal cancer.Materials and methodsData from patients with locally advanced primary esophageal cancer who received SEMS placement with or without prior chemotherapy were retrospectively reviewed. Patients were grouped according to prior palliative therapy: group A (n = 41) had received SEMS only, and group B (n = 64) had received palliative chemotherapy prior to SEMS placement. Patients’ age, stricture length, tumor location...
Source: Abdominal Imaging - Category: Radiology Source Type: research
This study assessed the risk factors of fistula based on clinical information on patients with chemoradiotherapy for T4-EC.MethodsWe retrospectively reviewed the clinical data of 59 T4-EC patients who had squamous cell carcinoma without any fistula before receiving definitive or palliative chemoradiotherapy.ResultsA fistula was observed in 18 patients (31%) throughout their clinical course. The overall survival in the fistula group was significantly shorter than that in the non-fistula group (259 vs. 346  days;p = 0.0341). The axial tumor size on computed tomography (CT) was confirmed as an independent r...
Source: Esophagus - Category: Gastroenterology Source Type: research
Brain metastases deriving from esophageal cancer are very rare with scarce data available concerning these patients’ outcome. We, therefore, evaluated outcome after surgical resection followed by radiotherapy of brain metastasis from esophageal cancer. A retrospective analysis was conducted on consecutive patients undergoing resection of brain metastasis from esophageal cancer in 2 neuro-oncological centers between 2008 and 2018. Clinical and demographic data were retrieved from electronic patient charts. Post-treatment survival was calculated using Kaplan–Meier estimates. Twenty-five patients were identified...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
This study is a retrospective comparative cohort which reviewed all patients diagnosed with oesophageal cancer by the Frere Hospital and GSH endoscopy units from January to December 2015. Independent prospective electronic databases for the two hospitals were merged for comparative analysis. RESULTS: During the study period, 346 and 108 patients were diagnosed with oesophageal cancer at Frere Hospital and GSH respectively. The rate of curative intended intervention was similarly low, with 3% of cases at Frere Hospital undergoing oesophagectomy or definitive radiotherapy as compared to 5% at GSH (p=0.48). In terms of pa...
Source: South African Journal of Surgery - Category: Surgery Tags: S Afr J Surg Source Type: research
This study aimed to assess the frequency and severity of clinical characteristics associated with late presentation of patients with OSCC presenting to a cancer referral centre in KwaZulu-Natal, South Africa. METHODS: A prospective consecutive series of patients presenting with confirmed OSCC treated at Greys Hospital in 2016/2017 were enrolled. Data collected included: age, gender, home language, referral centre, clinical and laboratory characteristics: dysphagia score, Eastern Cooperative Oncology Group (ECOG) performance status, body mass index (BMI), serum albumin, tumour pathology and treatment administered. R...
Source: South African Journal of Surgery - Category: Surgery Tags: S Afr J Surg Source Type: research
Incurable oesophageal cancer patients are often affected by existential distress and deterioration of quality of life. Knowledge about the life situation of this patient group is important to provide relevant ...
Source: BMC Palliative Care - Category: Palliative Care Authors: Tags: Research article Source Type: research
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