Serum Amyloid P and a Dendritic Cell –Specific Intercellular Adhesion Molecule-3–Grabbing Nonintegrin Ligand Inhibit High-Fat Diet–Induced Adipose Tissue and Liver Inflammation and Steatosis in Mice

High-fat diet (HFD) –induced inflammation is associated with a variety of health risks. The systemic pentraxin serum amyloid P (SAP) inhibits inflammation. SAP activates the high-affinity IgG receptor Fcγ receptor I (CD64) and the lectin receptor dendritic cell–specific intercellular adhesion molecule-3–grabbing nonintegrin (CD209). Herein, we show that for mice on an HFD, injections of SAP and a synthetic CD209 ligand (1866) reduced HFD-increased adipose and liver tissue inflammation, adipocyte differentiation, and lipid accumulation in adipose tissue.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Regular article Source Type: research