Severe Fungal Infections Following Blunt Traumatic Injuries: A 5-Year Multicenter Descriptive Study
Post-traumatic fungal infections are an uncommon (2-17% of all fungal infections are post-traumatic), yet life threatening complication secondary to major traumatic injury, that develop when fungal spores inoculate damaged tissue at the injury or wound site, leading to aggressive proliferation of spores and potential angioinvasion. [1-5] Sometimes characterized as a concomitant condition of a major traumatic injury, post-traumatic fungal infections can compromise the immune system, rapidly causing vessel thrombosis and tissue necrosis from a wound site or systemically.
CONCLUSIONS: The present findings suggest that the serum sdLDL cholesterol level is a relevant biomarker for the future development of CHD that offers benefit beyond the serum LDL cholesterol level and a possible therapeutic target to reduce the burden of CHD in a Japanese community. PMID: 31708527 [PubMed - as supplied by publisher]
ConclusionsDuplex ultrasound has significant limitations in the initial evaluation of patients with suspected SCV thrombosis, with false-negative results in 21% of patients with proven VTOS. This is rarely acknowledged in ultrasound reports, but false-negative ultrasound studies have the potential to delay definitive imaging, thrombolysis, and further treatment for VTOS. Initial false-negative ultrasound results are associated with progressive thrombus extension and a more frequent need for SCV bypass reconstruction at the time of surgical treatment.Graphical Abstract
Publication date: January 2020Source: Epilepsy &Behavior, Volume 102Author(s): Rachael Rosales, Barbara Dworetzky, Gaston BasletAbstractBackgroundPrevious literature suggests that cognitive-emotion processing contributes to the pathogenesis of psychogenic nonepileptic seizures (PNES). Characterization of alterations in cognitive-emotion processing in PNES could inform treatment.MethodsIn this descriptive, cross-sectional study, 143 patients with video electroencephalogram (EEG) confirmed PNES were prospectively recruited. Patients completed self-report questionnaires on emotion perception (Trait Meta-Mood Scale (TMMS) ...
Authors: Wu Z, Ma Y PMID: 31707863 [PubMed - as supplied by publisher]
Authors: Kunutsor SK, Mäkikallio TH, Laukkanen JA PMID: 31707862 [PubMed - as supplied by publisher]
(American Phytopathological Society) A recent Molecular Plant-Microbe Interactions article studies chitin-binding proteins from a soilborne fungus (Verticillium nonalfalfae) that causes vascular wilt in plants. This fungus binds a particular protein (VnaChtBP) to chitin in order to abolish the host plant's chitin-triggered burst of reactive oxygen species and shield the fungus from being digested by the plant.
In conclusion, tetramethylpyrazine protected BMECs and inhibited platelets adhesion to BMECs after OGD/R injury, which was partially mediated by inhibiting P38 MAPK and NF-κB signaling pathways.
AbstractLow-molecular-weight heparins (LMWHs) are the mainstay of the prophylaxis and treatment of venous thromboembolism (VTE). Due to their renal elimination, the risk of accumulation with the related bleeding risk may represent a limitation for the use of LMWHs in patients with chronic kidney disease (CKD) as the risk of major bleeding is increased in patients with creatinine clearance (CrCl)
Traumatic brain injury, a common cause of acquired epilepsy, is typical to find necrotic cell death within the injury core. The dynamic changes in astrocytes surrounding the injury core contribute to epileptic seizures associated with intense neuronal firing. However, little is known about the molecular mechanisms that activate astrocytes during traumatic brain injury or the effect of functional changes of astrocytes on seizures. In this comprehensive review, we present our cumulated understanding of the complex neurological affection in astrocytes after traumatic brain injury. We approached the problem through describing ...