Slim patients may develop Type 2 Diabetes if they don't prioritise losing fat around the middle

A new study from the University of Geneva, in Switzerland, found having a fatty liver might be another cause of type 2 diabetes because it can produce glucose on its own.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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AbstractNon-alcoholic fatty liver disease (NAFLD) is highly prevalent among individuals with type 2 diabetes. Although epidemiological studies have shown that NAFLD is associated with cardiovascular disease (CVD), it remains unknown whether NAFLD is an active contributor or an innocent bystander. Plasma lipids, low-grade inflammation, impaired fibrinolysis and hepatokines are potential mediators of the relationship between NAFLD and CVD. The Mendelian randomisation approach can help to make causal inferences. Studies that used common variants inPNPLA3,TM6SF2 andGCKR as instruments to investigate the relationship between NA...
Source: Diabetologia - Category: Endocrinology Source Type: research
Authors: Bellan M, Colletta C, Barbaglia MN, Salmi L, Clerici R, Mallela VR, Castello LM, Saglietti G, Carnevale Schianca GP, Minisini R, Pirisi M Abstract BACKGROUND: The prevalence of nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM) is high, though its severity is often underestimated. Our aim is to provide an estimate of the prevalence of severe NAFLD in T2DM and identify its major predictors. METHODS: T2DM patients (n=328) not previously known to have NAFLD underwent clinical assessment, transient elastography with measure of liver stiffness (LS) and controlled atten...
Source: Diabetes and Metabolism Journal - Category: Endocrinology Tags: Diabetes Metab J Source Type: research
Non-alcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease worldwide, affecting 25 –30% of the general population [1], with its prevalence reaching 55% in patients with type 2 diabetes mellitus (T2DM) [2] or even 90% in morbidly obese individuals [3]. NAFLD is characterized by fat accumulation in ≥5% of the hepatocytes, in the absence of excessive alcohol consumption or other secondary causes of liver diseases [4,5]. At the early stages of NAFLD, there is only liver steatosis (i.e.
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research
AbstractPurpose of reviewNonalcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease worldwide and yet remains largely underdiagnosed. However, whether a systematic screening in high-risk population for NAFLD should be performed remains debated.Recent findingsOver the past decade, a better knowledge of the natural history and epidemiology of NAFLD has identified high-risk population for NAFLD including obese and type 2 diabetes patients. Moreover, the presence of advanced fibrosis has been identified as the major determinant of overall and liver-related mortality. Moreover, several non-in...
Source: Current Hepatitis Reports - Category: Infectious Diseases Source Type: research
Conclusion Fibroscan results and low-density lipoprotein are potential diagnostic factors of liver fibrosis in diabetic patients with NAFLD. Further studies are necessary to verify liver fibrosis diagnostic tools and prognostic and genetic markers in diabetic patients.
Source: European Journal of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research
This article reviews the most updated information about NAFLD-related HCC and provides some insight into strategies that must be considered to reduce its potential disease burden.
Source: Hepatology International - Category: Infectious Diseases Source Type: research
AbstractPurpose of ReviewTo discuss the controversy over the effect of dietary fiber (DF) on (1) outcomes in critical illness, (2) microbiome and metabolic homeostasis, and (3) current evidence and guidelines regarding supplementation in critically ill patients.Recent FindingsIn healthy individuals, consumption of DF is widely known as a long-term protecting factor against colon cancer, cardiovascular disease, and other metabolic disorders like obesity, type 2 diabetes, and fatty liver disease; in hospitalized patients, DF may have a beneficial effect in the incidence of diarrhea, infections, and length of stay. But, what ...
Source: Current Nutrition Reports - Category: Nutrition Source Type: research
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are hepatic manifestations of metabolic syndrome and are increasing globally.1,2 Patients with NAFLD/NASH often present with either type 2 diabetes (T2D) or have insulin resistance and elevated fasting insulin levels, which are all established precursors for the development of diabetes and for adverse macrovascular sequalae.3 –5 NASH, T2D, and insulin resistance are thought to be growing in incidence and severity because of the increased availability of nutrients and consequent overnutrition.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
Abstract AIMS: Recent epidemiological studies have suggested an association between sarcopenia and non-alcoholic fatty liver disease (NAFLD) in the general population, prompting our investigation into the gender-specific association between sarcopenia and NAFLD in patients with type 2 diabetes mellitus (T2DM). METHODS: In this cross-sectional study, 4210 patients with T2DM were recruited from the Seoul Metabolic Syndrome Cohort. Appendicular skeletal muscle mass (ASM) was estimated from bioimpedance analysis measurements, and the skeletal muscle mass index (SMI) was calculated by dividing the sum of ASM by bo...
Source: Diabetes and Metabolism - Category: Endocrinology Authors: Tags: Diabetes Metab Source Type: research
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Source: International Journal of Environmental Health Research - Category: Environmental Health Authors: Source Type: research
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