Admedus Turns Attention to TAVR Program

Change is in the air for Admedus. The Brisbane, Australia-based company is selling off its CardioCel and VascuCel businesses to LeMaitre Vascular. The deal would give Admedus the space to focus on its transcatheter aortic valve replacement products. Under the agreement terms, Admedus receives $A22.8 million upfront followed by deferred payments of $A1 million each at 12 months and at 36 months. Additionally, the company could receive up to $A11.4 million in earn-out payments. Admedus said it retains manufacturing rights for up to three years and will continue manufacturing CardioCel and VascuCel at its Malaga facility in Western Australia for LeMaitre. The manufacturing agreement ensures Admedus a 20% margin over cost. Surgeons use CardioCel products to treat congenital heart defects, vessel and cardiovascular repairs, and peripheral vascular reconstruction. VascuCelis used as a patch in great vessel repair, peripheral vascular reconstruction and suture line buttressing. The firm is now configured to focus on product innovation led by the TAVR program and other large market opportunities based on its scientifically and commercially validated ADAPT platform. "Admedus plans its first-in-human studies for its single-piece 3D aortic valve in 2020,” Admedus CEO, Wayne Paterson, said in a release. “Based on Admedus' current laboratory and animal study findings - combined with the highly differentiated anti-calcification properties of all pro...
Source: MDDI - Category: Medical Devices Authors: Tags: Business Cardiovascular Source Type: news

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Publication date: Available online 3 June 2020Source: The Annals of Thoracic SurgeryAuthor(s): Martin T. Yates, Marjan Jahangiri
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Authors: Poulin A, Beaupré F, Gravel C, Hadjadj S, Bernier M, Beaudoin J, O'Connor K, Ferreira-Neto AN, Wintzer J, Dumont E, Dagenais F, Rodés-Cabau J, Paradis JM Abstract BACKGROUND: Many patients referred for a MitraClip intervention are finally refused for this intervention, and data are very scarce on their outcomes. Our study sought to determine the characteristics and outcomes of patients who are referred to a mitral valve clinic and are finally denied from a percutaneous mitral edge-to-edge repair. METHODS: A total of 210 patients referred to our clinic for severe mitral regurgitation were ...
Source: The Journal of Invasive Cardiology - Category: Cardiology Tags: J Invasive Cardiol Source Type: research
AbstractAlthough ex vivo simulation is a valuable tool for surgical optimization, a disease model that mimics human aortic regurgitation (AR) from cusp prolapse is needed to accurately examine valve biomechanics. To simulate AR, four porcine aortic valves were explanted, and the commissure between the two largest leaflets was detached and re-implanted 5  mm lower to induce cusp prolapse. Four additional valves were tested in their native state as controls. All valves were tested in a heart simulator while hemodynamics, high-speed videography, and echocardiography data were collected. Our AR model successfully reproduc...
Source: Journal of Cardiovascular Translational Research - Category: Cardiology Source Type: research
Am J Perinatol DOI: 10.1055/s-0040-1712964 Objective Prematurity and low birth weight (LBW) are risk factors for increased morbidity and mortality in infants with congenital heart defects (CHDs). We sought to describe survival, inhospital morbidities, and 2-year neurodevelopmental follow-up in LBW infants with CHD. Study Design We included infants with birth weight (BW)
Source: American Journal of Perinatology - Category: Perinatology & Neonatology Authors: Tags: Original Article Source Type: research
CONCLUSIONS: Aortic valve repair is a durable and effective surgical procedure associated with low early and late mortality. Aortic valve reconstruction in patients with acute type A aortic dissection yields good long-term results. PMID: 32486628 [PubMed - as supplied by publisher]
Source: Polish Heart Journal - Category: Cardiology Authors: Tags: Kardiol Pol Source Type: research
Researchers using a hybrid PET/MRI scanner detected a link between degenerative...Read more on AuntMinnie.comRelated Reading: 4 core applications of cardiovascular 3D printing Cardiac ultrasound at bedside boosts disease diagnosis ACC: Echocardiography identifies patients for valve repair Right heart quantification awareness: Part 6
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Publication date: June 2020Source: IJC Heart &Vasculature, Volume 28Author(s): Waqas Ullah, Yasar Sattar, Maryam Mukhtar, Hafez M. Abdullah, Vincent M. Figueredo, Donald C. Haas, David L. Fischman, M. Chadi Alraies
Source: IJC Heart and Vasculature - Category: Cardiology Source Type: research
European Journal of Heart Failure, EarlyView.
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Editorial Comment Source Type: research
European Journal of Heart Failure, EarlyView.
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Editorial Comment Source Type: research
AbstractAimsThe aim of this study was to compare the outcomes of surgical mitral valve repair or replacement (sMVR) and percutaneous edge ‐to‐edge repair using MitraClip (pMVR) in patients with severe left ventricular dysfunction affected by functional mitral regurgitation (FMR).Methods and resultsWe retrospectively identified 132 patients with left ventricular ejection fraction (LVEF)  ≦ 30% submitted to sMVR (n = 47) or pMVR (n = 85) for FMR at our centre from January 2013 to December 2017. To adjust for baseline imbalances, we used a propensity score matching by age, logistic EuroSCOR...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
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