Identification of a γc Receptor Antagonist that Prevents Reprogramming of Human Tissue-resident Cytotoxic T Cells by IL15 and IL21

Gamma chain ( γc) cytokines (interleukin 2 [IL2], IL4, IL7, IL9, IL15 and IL21) signal via a common γc receptor. IL2 regulates the immune response, whereas IL21 and IL15 contribute to development of autoimmune disorders, including celiac disease. We investigated whether BNZ-2, a peptide designed to inhibit IL15 and IL21, blocks these cytokines selectively and its effects on intraepithelial cytotoxic T cells.

Source: Gastroenterology - October 13, 2019 Category: Gastroenterology Authors: Cezary Ciszewski, Valentina Discepolo, Alain Pacis, Nick Doerr, Olivier Tastet, Toufic Mayassi, Mariantonia Maglio, Asjad Basheer, Laith Q. Al-Mawsawi, Peter Green, Renata Auricchio, Riccardo Troncone, Thomas A. Waldmann, Nazli Azimi, Yutaka Tagaya, Luis Source Type: research