TNFR2 associates with FoxP3 stability and identifies asubset of regulatory T cells that are specifically expanded by anti ‐TNF treatments in rheumatoid arthritis

ConclusionTNFR2 expression identifies a subset of Tregscharacterized by stable expression of Foxp3 via genehypomethylation, whose adoptive transfer ameliorates experimental inflammation. Expansion and activation of these TNFR2+Tregs may be one of the mechanisms by which anti ‐TNF‐α agents control inflammation in RA but not SpA.

Source: Arthritis and Rheumatology - October 13, 2019 Category: Rheumatology Authors: Fran çois Santinon, Maxime Batignes, MajdaLyna Mebrek, Jerôme Biton, Clavel Gaëlle, Roxane Hervé, Delphine Lemeiter, Magali Breckler, Florence Busato, Jorg Tost, Marianne Ziol, Marie‐Christophe Boissier, Patrice Decker, Luca Semerano, Tags: FULL LENGTH Source Type: research