GSE120750 Hi-C guided assemblies reveal conserved regulatory topologies on X and autosomes despite extensive genome shuffling [ChIP-seq]

Contributors : Gina Renschler ; Gautier Richard ; Claudia I Valsecchi ; Sarah Toscano ; Laura Arrigoni ; Fidel Ramirez ; Asifa AkhtarSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Drosophila busckii ; Drosophila virilisWe used an approach combining PacBio data and published Illumina reads to de novo assemble D. busckii contigs. We generated Hi-C data from D. busckii embryos to order these contigs into chromosome-length scaffolds. For D. virilis we generated Hi-C data to order and orient the published Dvir_caf1 scaffolds into chromosome-length assemblies. Furthermore, we compared Hi-C matrices from these two new assemblies with D. melanogaster with respect to synteny blocks and dosage compensation as a chromosome-wide gene-regulatory mechanism.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Drosophila busckii Drosophila virilis Source Type: research
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