Slit neuronal secretion coordinates optic lobe morphogenesis in Drosophila.

Slit neuronal secretion coordinates optic lobe morphogenesis in Drosophila. Dev Biol. 2019 Oct 10;: Authors: Caipo L, González-Ramírez MC, Guzmán-Palma P, Contreras EG, Palominos T, Fuenzalida-Uribe N, Hassan BA, Campusano JM, Sierralta J, Oliva C Abstract The complexity of the nervous system requires the coordination of multiple cellular processes during development. Among them, we find boundary formation, axon guidance, cell migration and cell segregation. Understanding how different cell populations such as glial cells, developing neurons and neural stem cells contribute to the formation of boundaries and morphogenesis in the nervous system is a critical question in neurobiology. Slit is an evolutionary conserved protein essential for the development of the nervous system. For signaling, Slit has to bind to its cognate receptor Robo, a single-pass transmembrane protein. Although the Slit/Robo signaling pathway is well known for its involvement in axon guidance, it has also been associated to boundary formation in the Drosophila visual system. In the optic lobe, Slit is expressed in glial cells, positioned at the boundaries between developing neuropils, and in neurons of the medulla ganglia. Although it has been assumed that glial cells provide Slit to the system, the contribution of the neuronal expression has not been tested. Here, we show that, contrary to what was previously thought, Slit protein provided by medulla neurons ...
Source: Developmental Biology - Category: Biology Authors: Tags: Dev Biol Source Type: research