Adverse Renal Response to Decongestion in the Obese Phenotype of Heart Failure with Preserved Ejection Fraction

Obesity is associated with inflammation, neurohormonal activation and plasma volume expansion.1,2 Patients with heart failure (HF) with preserved ejection fraction (HFpEF) and obesity display a number of pathophysiologic features that differentiate them from non-obese patients, including greater plasma volume expansion, right ventricular (RV) dysfunction, cardiomegaly, and pericardial restraint.3 This mileau sets the stage for enhanced ventricular interaction, whereby RV overload (as with decompensation) interferes with left ventricular (LV) filling to impair cardiac output.

Source: Journal of Cardiac Failure - October 12, 2019 Category: Cardiology Authors: Yogesh N.V. Reddy, Masaru Obokata, Jeffrey M. Testani, G. Michael Felker, W.H. Wilson Tang, Omar F. Abou-Ezzeddine, Jie-Lena Sun, Hrishikesh Chakrabothy, Steven McNulty, Sanjiv J. Shah, Gregory D. Lewis, Lynne W. Stevenson, Margaret M. Redfield, Barry A. Source Type: research