Cancer screening in adults with down syndrome, a proposal.

CONCLUSION: The specific tumor profile in DS warrants an adapted screening program for breast, colon, cervical and testicular neoplasia. PMID: 31605815 [PubMed - as supplied by publisher]
Source: European Journal of Medical Genetics - Category: Genetics & Stem Cells Authors: Tags: Eur J Med Genet Source Type: research

Related Links:

Authors: Riva G, Mancuso V, Cavedoni S, Stramba-Badiale C Abstract INTRODUCTION: Neurological diseases frequently cause adult-onset disability and have increased the demand for rehabilitative interventions. Neurorehabilitation has been progressively relying on computer-assisted programs and, more recently, on virtual reality (VR). Current reviews explore VR-based neurorehabilitation for assessing and treating the most common neurological pathologies. However, none of them explored specifically the impact of VR on multiple cognitive domains. AREAS COVERED: The present work is a review of six years of literature ...
Source: Expert Review of Medical Devices - Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research
Publication date: Available online 23 September 2020Source: Research in Developmental DisabilitiesAuthor(s): Matilde Taddei, Sara Bulgheroni
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
Publication date: November 2020Source: Research in Developmental Disabilities, Volume 106Author(s): Thomas Jürgen Klotzbier, Katharina Bühler, Benjamin Holfelder, Nadja Schott
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
In this study, novel hollow gold nanoparticles (HGNPs) were used as drug carriers, and in order to improve the targeting ability of HGNPs to a lung tumor site, polyoxyethylene sorbitol oleate (PSO) was chosen here as a target ligand since it can be specifically recognized by the low-density lipoprotein (LDL) receptor which is usually over expressed on A549 lung cancer cells. In this way, a PSO-modified doxorubicin-loaded HGNP drug delivery system (PSO-HGNPs-DOX) was constructed and its physicochemical properties, photothermal conversion ability, and drug release of PSO-HGNPs-DOX was investigated. Further, the effects of tr...
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
Authors: Hong D, Zhao HM Abstract Under the hydrothermal reaction condition, we prepared a new 3D Eu(III)-based coordination polymer (CP) [Eu(H2-DHBDC)0.5(DHBDC)0.5 (H2O)2]n·H2O (1, H4-DHBDC = 2,5-dihydroxy-1,4-terephthalic acid). Furthermore, we assessed the inhibitory influence on cervical cancer cells of this compound. Firstly, for testing the anti-viability of the compound against cervical cancer cells, the Cell Counting Kit-8 (CCK-8) assay was carried out. Then reactive oxygen species (ROS) detection kit was used to determine the ROS accumulation in the cervical cancer cells. Finally, after the Annexin ...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
CONCLUSIONS: iSystemic C. septicum infection without a traumatic cause has been associated with malignancy, although an initial presentation of endophthalmitis has rarely been reported. In cases of clostridial endogenous endophthalmitis, investigation for colorectal carcinoma is indicated. PMID: 32966149 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
National Commission for Persons with Disabilities proposes mobile app for persons with disabilities and their families in addition to creation of an ID Card for persons with disabilities
Source: Disabled World - Category: Disability Tags: Disability Information Source Type: news
Publication date: Available online 23 September 2020Source: The Annals of Thoracic SurgeryAuthor(s): Kiyomichi Mizuno, Mitsuhiro Isaka, Mototsugu Ono, Takamitsu Hayakawa, Yukihiro Terada, Yoshiyuki Yasuura, Hiroyuki Kayata, Hayato Konno, Hideaki Kojima, Tetsuya Mizuno, Takanori Kawabata, Yasuhisa Ohde
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
We report a label-free and "signal-on" homogeneous photoelectrochemical cytosensing system for ultrasensitive detection of cancer cells, which is a truly homogeneous PEC cytosensing system without the photoactive material immobilization and target recognition probe modification, providing a new avenue in early and accurate cancer diagnosis and clinical analysis. PMID: 32959814 [PubMed - in process]
Source: Chemical Communications - Category: Chemistry Authors: Tags: Chem Commun (Camb) Source Type: research
da CA Abstract Cells rely on protein homeostasis to maintain proper biological functions. Dysregulation of protein homeostasis contributes to the pathogenesis of many neurodegenerative diseases and cancers. Ubiquilins (UBQLNs) are versatile proteins that engage with many components of protein quality control (PQC) machinery in cells. Disease-linked mutations of UBQLNs are most commonly associated with amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other neurodegenerative disorders. UBQLNs play well-established roles in PQC processes, including facilitating degradation of substrates through...
Source: The Biochemical Journal - Category: Biochemistry Authors: Tags: Biochem J Source Type: research
More News: Breast Cancer | Cancer | Cancer & Oncology | Cervical Cancer | Colon Cancer | Colorectal Cancer | Disability | Down's Syndrome | Genetics | Testicular Cancer | Ultrasound | Women