Expression of Neuroectodermal Markers in Atypical Fibromas in Two Dwarf Hamsters (Phodopus spp.)
Publication date: October 2019Source: Journal of Comparative Pathology, Volume 172Author(s): K. Pertl, M. Borchers, W. Baumgärtner, P. WohlseinSummaryA 2-year-old male Djungarian hamster (Phodopus sungorus) and a 1-year-old male Roborovski hamster (Phodopus roborovskii) were presented with expansile subcutaneous masses. The well-demarcated, firm, grey, multilobulated nodules displayed an homogeneous, white–grey cut surface. Histological examination revealed a neoplasm of variable cellularity consisting of spindle-shaped to polygonal ‘ganglion cell-like’ cells with abundant, amphophilic, vacuolated cytoplasm. Immunohistochemically, the tumour cells were labelled intensely for vimentin and nestin, moderately for neuron specific enolase and weakly for melan-A. The histological and immunohistochemical findings were suggestive of an atypical fibroma with evidence of a neuroectodermal phenotype.
ConclusionThe developed image analysis methods were more time-saving and user-independent than established approaches. Moreover, by using adaptive thresholding, we could assess images with large variations in background intensity. These tools may prove valuable in the quantitative analysis of axonal and dendritic outgrowth from numerous in vitro models used in neuroscience.
Publication date: Available online 13 November 2019Source: Sensing and Bio-Sensing ResearchAuthor(s): Ammar Aldaoud, Samuel Lui, Kai Sheng Keng, Sarina Moshfegh, Artemio Soto-Breceda, Wei Tong, Jean-Michel Redoute, David J. Garrett, Yan T. Wong, Steven PrawerAbstractBiomedical electronic implants require a power source to operate. Miniaturised implants can preclude batteries and as implant dimensions reduce further, inductive power transfer no longer becomes the optimum strategy for wireless power delivery. Wide dipole antennas are proposed as an alternative power transmitter for long and thin implants. A miniaturised bioe...
Eye, Published online: 13 November 2019; doi:10.1038/s41433-019-0650-5Macular ganglion cell complex thinning in children with visual field defects due to central nervous system pathology
Human Gene Therapy, Ahead of Print.
Conclusions Leiomyoma is an important consideration when developing a differential diagnosis for primary benign masses in the hand. We hope that this comprehensive review can provide increased awareness of this tumor type.
ConclusionWe observed a close relationship between the CGRP containing C-fibers and the A δ-fibers containing the CGRP-receptor elements, suggesting a point of axon-axon interaction for the released CGRP and a site of action for gepants and the novel mAbs to alleviate migraine.
We present a rare occurrence of Chondromyxoid fibroma (CMF) in proximal 3rd humerus. 28 year old male with proximal humeral pain had a lesion in the proximal 3rd humerus on X-ray. Since, it appeared as benign lesion and small in size (radiologically looked like intra-osseous ganglion) we decided for excisional biopsy. The histopathological examination revealed that it was Chondromyxoid fibroma.
CONCLUSION:: In the deep palmar space of the hand, pathologies are closely associated with tendons, muscles, and neurovascular structures. Preoperative magnetic resonance imaging is helpful for the preoperative diagnosis, evaluating tumor extension, and successful surgical planning. Level of Evidence: IV Therapautic. PMID: 30955477 [PubMed - in process]
We examined the relationship between pre-operative clinical diagnosis, radiological diagnosis (ultrasonography (US) and magnetic resonance imaging (MRI)) and histopathological findings of soft tissue lesions of the hand. A retrospective review of 62 patients undergoing excision of soft tissue masses of the hand between 2015 and 2018 was conducted. The most common diagnoses were: ganglion (n=23), fibroma (n=8), giant cell tumour (GCT) (n=6) and vascular malformation (n=4). 31 patients underwent pre-operative imaging with US and/or MRI.
Abstract There is little discussion of tumors arising in the digits in the dermatology literature. The patient with an undifferentiated mass of the finger is frequently encountered in the clinic, and variances in presentation of common and uncommon entities pose a challenge that may prompt further investigation for proper diagnosis and treatment. In this review, the authors illustrate the approach and work‐up of an unknown digit mass of a 45‐year‐old female patient. They go on to discuss the presentation and treatment of common tumor lesions of the finger likely to be encountered in the dermatologist's clinic includi...