Expression of Neuroectodermal Markers in Atypical Fibromas in Two Dwarf Hamsters (Phodopus spp.)

Publication date: October 2019Source: Journal of Comparative Pathology, Volume 172Author(s): K. Pertl, M. Borchers, W. Baumgärtner, P. WohlseinSummaryA 2-year-old male Djungarian hamster (Phodopus sungorus) and a 1-year-old male Roborovski hamster (Phodopus roborovskii) were presented with expansile subcutaneous masses. The well-demarcated, firm, grey, multilobulated nodules displayed an homogeneous, white–grey cut surface. Histological examination revealed a neoplasm of variable cellularity consisting of spindle-shaped to polygonal ‘ganglion cell-like’ cells with abundant, amphophilic, vacuolated cytoplasm. Immunohistochemically, the tumour cells were labelled intensely for vimentin and nestin, moderately for neuron specific enolase and weakly for melan-A. The histological and immunohistochemical findings were suggestive of an atypical fibroma with evidence of a neuroectodermal phenotype.
Source: Journal of Comparative Pathology - Category: Pathology Source Type: research

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ConclusionThe developed image analysis methods were more time-saving and user-independent than established approaches. Moreover, by using adaptive thresholding, we could assess images with large variations in background intensity. These tools may prove valuable in the quantitative analysis of axonal and dendritic outgrowth from numerous in vitro models used in neuroscience.
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Eye, Published online: 13 November 2019; doi:10.1038/s41433-019-0650-5Macular ganglion cell complex thinning in children with visual field defects due to central nervous system pathology
Source: Eye - Category: Opthalmology Authors: Source Type: research
Human Gene Therapy, Ahead of Print.
Source: Human Gene Therapy - Category: Genetics & Stem Cells Authors: Source Type: research
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Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Review Paper Source Type: research
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Source: The Journal of Headache and Pain - Category: Neurology Source Type: research
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Source: Current Medicine Research and Practice - Category: General Medicine Source Type: research
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Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - Category: Cosmetic Surgery Authors: Source Type: research
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Source: International Journal of Dermatology - Category: Dermatology Authors: Tags: Review Source Type: research
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