Expression of Neuroectodermal Markers in Atypical Fibromas in Two Dwarf Hamsters (Phodopus spp.)

Publication date: October 2019Source: Journal of Comparative Pathology, Volume 172Author(s): K. Pertl, M. Borchers, W. Baumgärtner, P. WohlseinSummaryA 2-year-old male Djungarian hamster (Phodopus sungorus) and a 1-year-old male Roborovski hamster (Phodopus roborovskii) were presented with expansile subcutaneous masses. The well-demarcated, firm, grey, multilobulated nodules displayed an homogeneous, white–grey cut surface. Histological examination revealed a neoplasm of variable cellularity consisting of spindle-shaped to polygonal ‘ganglion cell-like’ cells with abundant, amphophilic, vacuolated cytoplasm. Immunohistochemically, the tumour cells were labelled intensely for vimentin and nestin, moderately for neuron specific enolase and weakly for melan-A. The histological and immunohistochemical findings were suggestive of an atypical fibroma with evidence of a neuroectodermal phenotype.
Source: Journal of Comparative Pathology - Category: Pathology Source Type: research