The Effect of the Twin Block Compared With Trigger Point Injections in Subjects With Masticatory Myofascial Pain: A Pilot Study

ConclusionThe twin block is effective in the long-term management of masticatory myofascial pain as compared to trigger point injections.Trial RegistrationClinicalTrials.gov Identifier: NCT03870191
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research

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ConclusionsA PBPK model of elagolix was developed, verified, and applied to characterize the disposition interplay between CYP3A4 and OATP1B1, and to predict the DDI potential of elagolix as a perpetrator under dosing conditions that were not tested clinically. PBPK model-based predictions were used to support labeling language for DDI recommendations of elagolix.
Source: Clinical Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research
The American population is getting older and sicker. More Americans are facing life-threatening illness when approaching end of life. Palliative care has grown to meet the complex needs of this population. And yet, according to a 2017 article in the journal Palliative Care, many people living with a chronic life-threatening illness either do not receive any palliative care, or receive services only in the last phase of their illness. The National Consensus Project Clinical Practice Guidelines for Quality Palliative Care also addressed this issue, stating that a goal of their recently updated guidelines is “to improve...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Caregiving End of life Pain Management Source Type: blogs
A Full Day of Pain Management for the Main Street Practitioner on December 7; mingle with faculty and attendees, learn and earn up to 6.0 AMA PRA Category 1 credits for $129.(PRWeb November 11, 2019)Read the full story at https://www.prweb.com/releases/painweekend_in_sacramento_ca_offers_ce_cme_education_to_meet_the_challenges_of_opioid_prescribing_regulation/prweb16679212.htm
Source: PRWeb: Medical Pharmaceuticals - Category: Pharmaceuticals Source Type: news
ConclusionThe HRQoL has considerable scope for improvement in patients with osteoporosis in the present study. Future osteoporosis management programmes should focus on improving HRQoL with specific attention to be given for patients with low serum vitamin D level, patients receiving multiple medications, patients having movement restriction, patients having spine kyphosis and those who have no friend or family member to remind them to take the medication.
Source: Journal of Pharmaceutical Health Services Research - Category: Drugs & Pharmacology Authors: Tags: Research Paper Source Type: research
Conclusions: IPMT is potentially feasible for high-risk USM patients. Future trials adequately powered for relevant endpoints are thus recommended.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
AbstractPurpose of ReviewInterstitial cystitis (IC) and IC-related conditions such as painful bladder syndrome (PBS), bladder pain syndrome (BPS), and hypersensitive bladder (HSB) have a similar symptomatic profile but probably different etiologies. A reasonable classification of these diseases/conditions is mandatory for clinical and investigational progress. We reviewed definition of current terminology and recent research evidence regarding IC and related conditions to propose a sensible classification system.Recent FindingsThe condition with Hunner lesions (Hunner type IC: HIC) is obviously distinct from other categori...
Source: Current Bladder Dysfunction Reports - Category: Urology & Nephrology Source Type: research
ConclusionMeloxicam can be considered as an alternative analgesic agent than some NSAIDs, tramadol, and salicylic acids in patients who have undergone the third molar extraction.
Source: Oral Surgery - Category: ENT & OMF Authors: Tags: REVIEW Source Type: research
AbstractContextRosa damascena Mill. is prescribed for the management of chest and abdominal pain, constipation, digestive disorders, menstrual bleeding and liver ailments.ObjectiveThe current review compiles up to date and complete information of whole plant ofR.  damascena with particular emphasis on its numerous scientifically proved pharmacological effects, traditional and folk medicinal uses.Key findingThe data on the pharmacological effects ofR.  damascena were collected from various databases such as PubMed, Wiley Online Library, Elsevier and Web of Science using the keywords like phytoconstituents, pharmac...
Source: Journal of Pharmacy and Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Review Source Type: research
DiscussionControlled trials are needed to determine the best rehabilitation approach for mTBI with persistent symptoms such as neck pain, headache and dizziness. This RCT will be crucial to guide future clinical management recommendations.Trial registrationClinicalTrials.gov Identifier -NCT03677661, Registered on September, 15th 2018.
Source: BMC Sports Science, Medicine and Rehabilitation - Category: Sports Medicine Source Type: research
The objective of this review was to determine the efficacy, safety, and cost of surgical versus nonsurgical management of symptomatic lumbar radiculopathy in adults.MethodsWe searched PubMed from January 1, 2007, to April 10, 2019 with hand searches of systematic reviews for studies prior to 2007. One reviewer extracted data and a second checked for accuracy. Two reviewers completed independent risk of bias and strength of evidence ratings.ResultsWe included seven RCTs (N = 1158) and three cost-effectiveness analysis. Surgery reduced leg pain by 6 to 26 points more than nonsurgical interventions as measured on a 0- to 100-...
Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research
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