Liraglutide improves vascular dysfunction by regulating a cAMP-independent PKA-AMPK pathway in perivascular adipose tissue in obese mice.

CONCLUSIONS: Liraglutide improved vascular dysfunction by modulating a cAMP-independent PKA-AMPK pathway in PVAT in HFD-induced obese mice. The findings provide a novel mechanism for the cardiovascular protection of liraglutide by modulating PVAT function in obesity.
PMID: 31605951 [PubMed - as supplied by publisher]

Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 8, 2019 Category: Drugs & Pharmacology Authors: Han F, Hou N, Liu Y, Huang N, Pan R, Zhang X, Mao E, Sun X Tags: Biomed Pharmacother Source Type: research