Dual roles of glutathione S-transferase mu 1 in the development and metastasis of hepatocellular carcinoma.

CONCLUSION: GSTM1 down-regulation may partially account for ROS-mediated oxidative damage and HCC carcinogenesis. GSTM1 also regulates tumor progression by disrupting the ROS-TP53 axis in HCC cells with different genetic backgrounds.
PMID: 31605953 [PubMed - as supplied by publisher]

Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 8, 2019 Category: Drugs & Pharmacology Authors: Lu Y, Zhou J, Zhang J, Wang Z, Yu Y, Miao M, Yao Q Tags: Biomed Pharmacother Source Type: research