Covalent triazine-based polyimine framework as a biocompatible pH-dependent sustained-release nanocarrier for sorafenib: An in vitro approach

Publication date: Available online 12 October 2019Source: Journal of Molecular LiquidsAuthor(s): Nazanin Mokhtari, Somayeh Taymouri, Mina Mirian, Mohammad DinariAbstractIn the present study, a novel polyimine-based covalent triazine framework (PI-CTF) was introduced as a promising biocompatible carrier for sorafenib (SFN) delivery. High specific surface area and porosity allowed us to achieve drug loading and encapsulation efficiency as high as 83% and 98%, respectively. The in vitro drug release study of SFN-loaded PI-CTF showed a sustained and pH-dependent release behavior in which acidic pH accelerated drug release compared with the neutral pH. Notably, cytotoxicity assay against L929 cells revealed the safety and biocompatibility of PI-CTF. Moreover, MTT assay against LNCaP prostate cancer cells expressed that the anticancer activity of SFN had no diminution after incorporating into PI-CTF. Thus, PI-CTF has envisaged as a great promise toward anti-cancer drug carrier.Graphical abstract
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research