A small molecule chaperone rescues the stability and activity of a cancer ‐associated variant of NAD(P)H:quinone oxidoreductase 1 in vitro

In this study, we show that a small molecular chaperone (N‐(2‐bromophenyl)pyrrolidine‐1‐sulfonamide) repopulates the native wild‐type conformation. As a consequence of th e stabilizing effect, the enzymatic activity of the P187S variant protein is strongly improved in the presence of the molecular chaperonein vitro.

Source: FEBS Letters - October 11, 2019 Category: Biochemistry Authors: Emilia Strandback, Wolf ‐Dieter Lienhart, Altijana Hromic‐Jahjefendic, Benjamin Bourgeois, Anja Högler, Daniel Waltenstorfer, Andreas Winkler, Klaus Zangger, Tobias Madl, Karl Gruber, Peter Macheroux Tags: RESEARCH ARTICLES Source Type: research