Secretory antibodies to citrullinated peptides in plasma and saliva from rheumatoid arthritis patients and their unaffected first-degree relatives.

CONCLUSION: Despite occurring in 19% of RA plasma, secretory ACPA was rare in both saliva and plasma among FDRs, even among those positive for conventional ACPA of non-mucosal origin. Longitudinal studies are warranted to determine whether circulating secretory ACPA occurs before or in parallel with the development of clinical arthritis.
PMID: 31605388 [PubMed - as supplied by publisher]

Source: Clinical and Developmental Immunology - October 11, 2019 Category: Allergy & Immunology Authors: Svärd A, Roos Ljungberg K, Brink M, Martinsson K, Sjöwall C, Rantapää Dahlqvist S, Kastbom A Tags: Clin Exp Immunol Source Type: research