Current anti-Alzheimer's disease effect of natural products and their principal targets.

Current anti-Alzheimer's disease effect of natural products and their principal targets.
J Integr Neurosci. 2019 Sep 30;18(3):327-339
Authors: Zhu Y, Peng L, Hu J, Chen Y, Chen F
Abstract
Various bioactive substances isolated from natural products play a pivotal role in the prevention and cure of neurodegenerative diseases, such as Alzheimer's disease. Currently, there are many theories about the pathogenesis of this disease. In this review we discuss among them, the cholinergic hypotheses, the Aβ toxicity hypothesis, and the tau dysfunction hypothesis. Multiple potential targets are a focus for the development of anti-AD drugs. There is an urgent need to develop more effective therapies to treat and delay the onset of the disease and to find safe and effective drugs. In this review, the recent progress of anti-AD effects and their principal targets are updated.
PMID: 31601083 [PubMed - in process]

Source: Journal of Integrative Neuroscience - September 29, 2019 Category: Neuroscience Authors: Zhu Y, Peng L, Hu J, Chen Y, Chen F Tags: J Integr Neurosci Source Type: research