Intermittent restraint-induced sympathetic activation attenuates hepatic steatosis and inflammation in a high fat-diet fed-mouse model.

Intermittent restraint-induced sympathetic activation attenuates hepatic steatosis and inflammation in a high fat-diet fed-mouse model. Am J Physiol Gastrointest Liver Physiol. 2019 Oct 11;: Authors: Lee SB, Kim HG, Lee JS, Kim WY, Lee MM, Kim YH, Lee JO, Kim HS, Son CG Abstract NAFLD is very prevalent worldwide, and is associated with insulin resistance and metabolic syndrome. Stress is physiological and biological response to maintain homeostasis of body against stressors while severe stress response is an important contributor to various illnesses including metabolic syndrome and brain disorders. We have evaluated the effects of intermittent restraint stress on NAFLD in a HFD-fed mouse model. C57/BL6 mice had free access to a 60% HFD for 8 weeks, with or without intermittent restraint stress (3 h) conducted 3 times a week. HFD administration increased fat accumulation in liver tissues. Unlike the stressed standard diet group, the levels of hepatic total cholesterol and triglycerides were significantly ameliorated in the HFD with stress group compared to the HFD alone group. These beneficial results were in accordance with serum levels of liver enzymes (AST, ALT) and hepatic levels of TNF-α and oxidative stress parameters (ROS, NO, and malondialdehyde). The intermittent restraint stress significantly attenuated the HFD-derived alterations in serum insulin levels, hepatic protein kinase B (AKT) activity and gene expression especial...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - Category: Physiology Authors: Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research