Synergistic effects of adipose-derived stem cells combined with decellularized myocardial matrix on the treatment of myocardial infarction in rats

Publication date: Available online 12 October 2019Source: Life SciencesAuthor(s): Liang Qiao, Yan Kong, Yingshen Shi, Aijun Sun, Ruijuan Ji, Chao Huang, Yuquan Li, Xiangqun YangAbstractAimsThe aims of the study are to investigate whether the combination of adipose-derived stem cells (ADSCs) with decellularized extracellular matrix (dECM) of myocardium can exert synergistic therapeutic effects on acute MI and the underlying mechanism.Main methodsMyocardial dECM from fresh porcine myocardium was prepared in an injectable gel, ADSCs were seeded into the myocardial dECM gels, and then the mixture was injected into the myocardium of the infarct border zone after acute MI, which was induced by ligating the left anterior descending coronary artery in male SD rats, to assess the therapeutic potential. The degree of fibrosis was detected by Masson's trichrome. The evaluation of cardiac function was performed by Electrocardiography.Key findingsMyocardial dECM (2.0%) had a suitable aperture and arrangement for cell growth, and also exhibited suitable biomechanical properties. Four-weeks after treatment in vivo, the combination of ADSCs and myocardial dECM could obviously increase angiogenesis, reduce the degree of fibrosis and decrease infarct size. Furthermore, the combination treatment exerted significant functional improvement. Compared with ADSCs or dECM group alone, the left ventricular ejection fraction (LVEF) in the combination group was 13.4% and 21.8% elevated, respectively.Sig...
Source: Life Sciences - Category: Biology Source Type: research

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ConclusionsAn increase in diagnostic and therapeutic procedures was reported in 2018, particularly in primary percutaneous coronary interventions. The use of the radial approach and complex procedures also increased. The number of structural procedures rose significantly, following the trend seen in recent years.ResumenIntroducción y objetivosLa Sección de Hemodinámica y Cardiología Intervencionista presenta su informe anual con los datos del registro de actividad correspondiente a 2018.MétodosLos centros españoles con laboratorio de hemodinámica proporcionan sus datos volun...
Source: Revista Espanola de Cardiologia - Category: Cardiology Source Type: research
HEART attack is considered a serious medical emergency and the risk of one happening is increased during winter. So how can you prevent the life-threatening condition? Making sure your home is the right temperature is the advice from TV doctor Dr Zoe Williams.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Analyst, 2019, Accepted Manuscript DOI: 10.1039/C9AN01679A, PaperKyu Shik Eom, Yijae Lee, Hye Won Seo, Ji Yoon Kang, Joon S. Shim, Soo Hyun Lee An excessive cholesterol level can lead to cardiovascular diseases, such as stroke, hypertension, and myocardial infarction. A non-invasive, painless method of determining the cholesterol in the blood would improve the... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
Authors: Nakagami F, Yamamoto K, Hagiya H, Rakugi H PMID: 31708545 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
This study is registered with the Netherlands Trial Registry, number NTR5263.FindingsWe screened patients for enrolment between Dec 3, 2015, and May 31, 2018. Patients completed baseline visits and started treatment between Dec 14, 2015, and July 2, 2018, and the last study visit of the last patient was Oct 4, 2018. Of 149 patients assessed for eligibility, 57 (38%) patients were excluded (predominantly because they did not meet one or several inclusion criteria, most often because of an absence of synovial inflammation or of flare-ups after NSAID washout) and 92 (62%) patients were eligible for inclusion. We randomly assi...
Source: The Lancet - Category: General Medicine Source Type: research
Conclusion: In conclusion, this study demonstrated that over-expression of Id2 preserved cardiac function and ameliorated adverse cardiac remodeling, which might be a promising treatment target for cardiac fibrosis and apoptosis.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
(Reuters Health) - People who have trouble falling asleep or staying asleep may be more likely to have a heart attack or stroke than individuals who don't have any sleep difficulties, a recent study suggests.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Publication date: Available online 11 November 2019Source: Canadian Journal of CardiologyAuthor(s): Yu Tan, Jinying Zhou, Chen Liu, Peng Zhou, Zhaoxue Sheng, Jiannan Li, Runzhen Chen, Li Song, Hanjun Zhao, Bo Xu, Runlin Gao, Hongbing YanAbstractBackgroundTrimethylamine N-oxide (TMAO) has been shown to promote the development of atherosclerosis. However, the relationship between plasma TMAO and neoatherosclerosis, an important underlying mechanism of very late stent thrombosis (VLST), is unknown.MethodsThis post hoc study investigated the association between TMAO and neoatherosclerosis in two independent cohorts. These incl...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
ConclusionsClaims- versus site-based (+CEC) follow-up identified similar overall cardiovascular event rates despite meaningful differences in the events detected. Randomized treatment effects were similar using the 2 methods, suggesting claims data could be used to support clinical research leveraging routinely collected data. This approach may lead to more effective evidence generation, synthesis, and appraisal of medical products and inform the strategic approaches toward the National Evaluation System for Health Technology.
Source: American Heart Journal - Category: Cardiology Source Type: research
Publication date: Available online 11 November 2019Source: American Heart JournalAuthor(s): Dan Yang, Connor Galen O'Brien, Gentaro Ikeda, Jay H. Traverse, Doris A. Taylor, Timothy D. Henry, Roberto Bolli, Phillip C. YangBackgroundMononuclear cells (MNCs) have been tested in clinical trials across multiple cardiovascular pathologies with mixed results. Major adverse cardiac events (MACE) and markers of cardiovascular capacity have been particularly challenging to interpret due to small size. This meta-analysis is aimed to assess the efficacy of MNC therapy in randomized clinical trials to identify the markers of efficiency...
Source: American Heart Journal - Category: Cardiology Source Type: research
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