Treatment with nitrite prevents reactive oxygen species generation in the corpora cavernosa and restores intracavernosal pressure in hypertensive rats

Publication date: Available online 11 October 2019Source: Nitric OxideAuthor(s): Natália A. Gonzaga, Gabriel T. do Vale, Carla B.P. da Silva, Lucas C. Pinheiro, Letícia N. Leite, Fernando S. Carneiro, José E. Tanus-Santos, Carlos R. TirapelliAbstractHypertension is a risk factor for erectile dysfunction (ED) and both conditions are associated with oxidative stress. Given that nitrite is described to display antioxidant effects, we hypothesized that treatment with nitrite would exert antioxidant effects attenuating both reactive oxygen species (ROS) generation in the corpora cavernosa (CC) and ED induced by hypertension. Two kidney, one clip (2K1C) hypertension was induced in male Wistar rats. Treatment with sodium nitrite (15 mg/kg/day, p.o., gavage) was initiated two weeks after surgery to induce hypertension and maintained for four weeks. Nitrite abrogated both the decrease in intracavernosal pressure and endothelial dysfunction of the CC induced by hypertension. Treatment with nitrite decreased hypertension-induced ROS generation in the CC assessed in situ using the fluorescent dye dihidroethidium (DHE) and with the lucigenin assay. Western immunoblotting analysis revealed that nitrite prevented the increase in Nox1 expression in the CC from 2K1C rats. Decreased concentrations of hydrogen peroxide (H2O2) were found in the CC from hypertensive rats and treatment with nitrite prevented this response. Treatment with nitrite increased the fluorescence of...
Source: Nitric Oxide - Category: Chemistry Source Type: research

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AbstractPurpose of ReviewAs the prevalence of diabetes mellitus grows worldwide, it is increasingly important to understand the commonly comorbid urologic conditions, hypogonadism and erectile dysfunction, in the setting of the diabetic man. The relationship between the diabetes, hypogonadism, and erectile dysfunction is complex with significant interplay among the disease processes and potential for unique management of the triad. The purpose of this review is to provide an update on the intertwined nature of these diseases in diabetics with special consideration for pathophysiology, diagnosis, and management.Recent Findi...
Source: Current Sexual Health Reports - Category: Sexual Medicine Source Type: research
This small scale cross-sectional study was done to identify the common systolic blood pressure pattern (dipping or non-dipping) among type 2 diabetic men with coexisting hypertension and erectile dysfunction(E...
Source: BMC Research Notes - Category: Research Authors: Tags: Research note Source Type: research
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Source: American Journal of Hypertension - Category: Cardiology Authors: Tags: Am J Hypertens Source Type: research
Case written and submitted by Ryan Barnicle MD, with edits by Pendell MeyersWhile vacationing on one of the islands off the northeast coast, a healthy 70ish year old male presented to the island health center for an evaluation of chest pain. The chest pain started about one hour prior to arrival while bike riding. It was a constant ache on the left side of his chest that forced him to stop cycling and call for an ambulance. It was radiating to his bilateral upper arms. It was associated with nausea but he denied dyspnea, dizziness, and headache.He explained that he had the same chest pain the day prior as well, on and off....
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
You're reading 8 Nootropics to Stimulate Your Brain This Fall, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. Nootropics is a term coined by Dr. Corneliu E. Giurgea to describe a class of drugs, supplements, and other synthetic and naturally occurring compounds that improve cognitive function in our brains. They’re often called “smart drugs,” as they can help us think faster and more efficiently. Although used by pretty much everyone, these nootropic supplements are especially popular among youn...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured health and fitness self improvement nootropics pickthebrain Source Type: blogs
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Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
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Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
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Source: Presse Medicale - Category: General Medicine Authors: Tags: Presse Med Source Type: research
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Source: Clinical Therapeutics - Category: Drugs & Pharmacology Authors: Tags: Clin Ther Source Type: research
Poor oral health has been linked with heart disease, high blood pressure and, more recently, erectile dysfunction. Here, we look at some of the everyday drugs that can cause oral issues.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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