Antitumor activity of Cuphea ignea extract against benzo(a)pyrene-induced lung tumorigenesis in Swiss Albino mice

Publication date: Available online 11 October 2019Source: Toxicology ReportsAuthor(s): Sherien K. Hassan, Amria M. Mousa, Nermin M. El-Sammad, Abeer H. Abdel-Halim, Wagdy K.B. Khalil, Elsayed A. Elsayed, Nayera Anwar, Michael W. Linscheid, Eman S. Moustafa, Amani N. Hashim, Mahmoud NawwarAbstractLung cancer has one of the highest mortality rates among various types of cancer and is the most frequent cancer in the world. The incidence of lung cancer is increasing rapidly, in parallel with an increased incidence of smoking. Effective chemoprevention may be an alternative strategy to control the incidence of lung cancer. Thus, the objective of current work was to ascertain the possible preventive and therapeutic efficacies of Cuphea ignea extract in a mouse model of lung tumorigenesis and its cytotoxicity toward the A549 human lung cancer cell line. Lung tumorigenesis was induced by the oral administration of benzo(a)pyrene (50 mg/kg b.w.) twice per week to Swiss albino mice for 4 weeks. Benzo(a)pyrene-treated mice were orally administered C. ignea (300 mg/kg body weight, 5 days/week) for 2 weeks before or 9 weeks after benzo(a)pyrene treatment, for a total of 21 weeks. At the end of the administration period, various parameters were measured in the serum and lung tissues. The results revealed that the oral administration of benzo(a)pyrene resulted in increases in relative lung weight, serum levels of tumor markers (ADA, AHH, and LDH), and the inflammatory marker N...
Source: Toxicology Reports - Category: Toxicology Source Type: research

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