ATM Whole Gene Deletion in an Italian Family with Hereditary Pancreatic Cancer: Challenges to cancer risk prediction associated with an 11q22.3 microdeletion

Pancreatic cancer is a rare cancer that carries a poor 5 year survival rate of approximately 5% [1]. Approximately 5% to 10% of individuals with pancreatic cancer report having a closely related family member also being diagnosed with pancreatic cancer [2]. Several known genetic syndromes, such as hereditary breast-ovarian cancer syndrome (HBOC) [3], Lynch syndrome [4], familial adenomatous polyposis [5], familial atypical multiple mole melanoma syndrome [6], hereditary pancreatitis [7], Peutz-Jeghers syndrome [8], and Li-Fraumeni syndrome [9] are associated with increased risk of pancreatic cancer.

Source: Cancer Genetics and Cytogenetics - October 11, 2019 Category: Genetics & Stem Cells Authors: Heleen H. Arts, Lorrie Lynch, Daria Grafodatskaya, Barry Eng, Lesley Malloy, John Duck, Robyn White, Crystal Woodside, Kathleen Bell, Kevin M. Zbuk, Elizabeth McCready Source Type: research