A novel Mn-Cu bimetallic complex for enhanced chemodynamic therapy with simultaneous glutathione depletion.

A novel Mn-Cu bimetallic complex for enhanced chemodynamic therapy with simultaneous glutathione depletion.
Chem Commun (Camb). 2019 Oct 11;:
Authors: Cao S, Fan J, Sun W, Li F, Li K, Tai X, Peng X
Abstract
A bimetallic complex, containing Mn(ii) and Cu(ii) moieties, was synthesized for chemodynamic therapy (CDT) of cancer. The complex was capable of generating a hydroxyl radical (˙OH) via a Fenton-like reaction involving a Mn complex, and simultaneously depleting glutathione via a Cu complex induced oxidative reaction, thereby enhancing the efficiency of CDT.
PMID: 31602444 [PubMed - as supplied by publisher]

Source: Chemical Communications - October 10, 2019 Category: Chemistry Authors: Cao S, Fan J, Sun W, Li F, Li K, Tai X, Peng X Tags: Chem Commun (Camb) Source Type: research