Burn patients with history of kidney transplant experience increased incidence of wound infection

Publication date: Available online 11 October 2019Source: BurnsAuthor(s): Helen Zhang, Weikai Qu, Munier Nazzal, Jorge OrtizAbstractObjectiveTo determine if history of kidney transplant is an independent risk factor for increased incidence of wound infection and other morbidities in burn patients.BackgroundWhile the goal of immunosuppression post-organ transplantation is to prevent graft rejection, it is often associated with significant adverse effects such as increased susceptibility to infection, drug toxicity, and malignancy. Burn injuries lead to a dysregulated hypermetabolic state and a compromised cutaneous barrier, which predisposes to infection and delayed wound healing. We surmise that a history of kidney transplant increases the risk of wound infection in in-hospital burn victims.MethodsA retrospective analysis was performed on 57,948 adults diagnosed in-hospital with a burn injury between 2008–2014, obtained from the Nationwide Inpatient Sample (NIS) by Healthcare Cost and Utilization Project (HCUP).Results103 burn victims (0.2%) with a history of kidney transplant (KTX) were identified. Compared to burn patients without a history of transplant (No-KTX), they were older (54.3 ± 13.8 vs 49.8 ± 18.7; p = 0.001), more likely be insured under Medicare (69.9% vs 31.1%; p 
Source: Burns - Category: Dermatology Source Type: research

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ConclusionsMarked differences in risk for ESKD across types of donor-recipient relationship were observed for Asian, black, and white donors. These findings warrant further validation with more robust data to better inform clinical practice guidelines.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
The meet-cute is neatly postponed in this entertaining story of two next-door neighbours, both seeing therapists and looking for loveMuch like the process of psychotherapy itself, patience is required for results while watching this modestly entertaining slow-burn Parisian romance fromC édric Klapisch, who pulls off a neat trick by bumping the meet-cute to the end of the film.What happens before his protagonists clap eyes on each other is a kind of emotional spring clean. Both of them, a man and woman in their early 30s, are struggling with anxiety and stress; they find their way to therapy and sift through their se...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Romance films Psychology France World news Science Europe Culture Paris Source Type: news
We present a reproducible although demanding surgical technique to perform a bipolar fresh osteochondral allograft transplantation of the patella and trochlea.
Source: Arthroscopy Techniques - Category: Surgery Source Type: research
Publication date: Available online 13 November 2019Source: Arthroscopy TechniquesAuthor(s): Burak Altintas, Frank Martetschläger, Erik M. Fritz, Ryan J. Warth, Joshua A. Greenspoon, Travis C. Burns, Nicole L. Anderson, Peter J. MillettAbstractSurgical exposure of the glenoid after previous coracoid process transfer is technically challenging as a result of distorted anatomy, obliterated soft-tissue planes, and adhesive scar tissue, which poses additional risk to adjacent neurovascular structures. The purpose of this article is to present a technique for glenoid exposure following coracoid transfer that involves tenoto...
Source: Arthroscopy Techniques - Category: Surgery Source Type: research
ConclusionsTherapeutic drug monitoring-guided meropenem may be a sound new therapeutic option in eradicating multidrug resistant Acinetobacter and offer a novel therapeutic option in the field of personalized medicine.
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Conditions:   Allogeneic Hematopoietic Stem Cell Transplant Recipient;   Donor;   Malignant Neoplasm Intervention:   Procedure: Biospecimen Collection Sponsors:   City of Hope Medical Center;   National Cancer Institute (NCI) Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Colorectal Cancer;   Liver Metastases;   Colorectal Liver Metastases Interventions:   Procedure: Liver transplantation Ltx;   Other: Best alternative care Sponsor:   Vastra Gotaland Region Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
By SAURABH JHA, MD Despite an area under the ROC curve of 1, Cassandra’s prophesies were never believed. She neither hedged nor relied on retrospective data – her predictions, such as the Trojan war, were prospectively validated. In medicine, a new type of Cassandra has emerged –  one who speaks in probabilistic tongue, forked unevenly between the probability of being right and the possibility of being wrong. One who, by conceding that she may be categorically wrong, is technically never wrong. We call these new Minervas “predictions.” The Owl of Minerva flies above its denominator. ...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Artificial Intelligence Data Medical Practice Physicians RogueRad @roguerad acute kidney injury AI deep learning machine learning predictions Saurabh Jha Source Type: blogs
Conclusions: We propose that epigenetics mechanisms involving microRNAs may integrate human transplantation tolerance mechanisms, and regulate key members of the cell death/survival signaling. miR-885-5p could favor cell survival in OT by diminishing the levels of CRADD/RAIDD and CASP3. Nonetheless, given the nature of any complex phenomenon in humans, only cumulative data will help to determine whether this microRNA differential profile may be related to the cause or consequence of operational tolerance. Introduction Despite its clinical success, allotransplantation still faces important challenges, such as preventi...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusion and Perspectives Collectively, previous studies showed that numerous types of TCMs protect against AKI via different mechanisms of action, including inhibiting inflammation, cell apoptosis, necroptosis, ferroptosis, and restraining oxidative stress etc. These data support the potential application of these TCMs as novel therapeutic agents in treating patients with AKI. Although some TCMs have entered preclinical trials, it is essential to initiate pre-clinical pharmacologic and toxicologic trials and clinical trials to evaluate the efficacy and safety of TCMs usage. Moreover, considering that some TCMs are dele...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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