The Impact of the New Hypertension Guidelines to Low-Dose Aspirin Prophylaxis Eligibility for the Prevention of Preeclampsia: A Cost-Benefit Analysis

Conclusion Despite the small change in aspirin prophylaxis, using ACC/AHA definition of hypertension still results in an annual cost-saving of $9.4 million in the United States when compared with JNC7. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: American Journal of Perinatology - Category: Perinatology & Neonatology Authors: Tags: Original Article Source Type: research

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ConclusionsMaternal background and obstetric parameters are more likely to influence the SGA rate than fresh embryo transfer conception. FET conception could be associated with an increase in LGA rate.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
Abstract BACKGROUND: Previous studies implicated cardiotonic steroids, including Na/K-ATPase inhibitor marinobufagenin (MBG), in the pathogenesis of preeclampsia (PE). We demonstrated that MBG induces fibrosis via mechanism involving inhibition of Fli1, a nuclear transcription factor and a negative regulator of collagen-1 synthesis. We hypothesized that PE blockade of increased MBG with antibody would lessen the fibrosis of umbilical arteries and lower the blood pressure in rats with PE. METHODS: We tested 36 pregnant Sprague-Dawley rats in which 12 were made hypertensive by 1.8% Na supplementation (days...
Source: American Journal of Hypertension - Category: Cardiology Authors: Tags: Am J Hypertens Source Type: research
Study points out dangers, provides tips on monitoring health of mother and baby.
Source: Washington Post: To Your Health - Category: Consumer Health News Authors: Source Type: news
(Massachusetts General Hospital) Women who have gestational hypertension or preeclampsia in at least one pregnancy will have higher cardiovascular risk than women without such a history, and that this elevated risk persists at least into their 60s.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
CONCLUSION: Compared to normal, fetuses with TGA-IVS undergo a complex redistribution of flow during the second half of the pregnancy with higher global pulmonary flow, lower ductal flow (with a negative diastolic flow at the end of pregnancy), and a smaller foramen ovale. In addition, fetal cardiac hemodynamic anomalies observed at 28-32 weeks of gestation were associated to lower postnatal tcSO2 . These observations may provide a better understanding of a premature closure of the foramen ovale and postnatal hypoxia that are specific to the physiology in TGA-IVS. This article is protected by copyri...
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Tags: Ultrasound Obstet Gynecol Source Type: research
AbstractIntroductionMidwife ‐led models of care have been subject of debate for many years. We conducted a study to compare intrapartum and neonatal mortality rates in midwife‐led (primary) versus obstetrician‐led (secondary) care at the onset of labour in low risk term women.Material and methodsWe performed an unmatched and a propensity score matched cohort study using data from the national perinatal audit registry (PAN) and from the national perinatal registry (PERINED) of the Netherlands. We included women with singleton pregnancies (without congenital anomalies or antepartum fetal death) who gave birth at term b...
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Conclusion SCT alone does not appear to be associated with adverse pregnancy outcomes. Race/ethnicity is a risk factor for adverse pregnancy outcomes. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text
Source: American Journal of Perinatology Reports - Category: Perinatology & Neonatology Authors: Tags: Original Article Source Type: research
Long non‑coding RNA NR_002794 is upregulated in pre‑eclampsia and regulates the proliferation, apoptosis and invasion of trophoblast cells. Mol Med Rep. 2019 Sep 24;: Authors: Ma Y, Liang X, Wu H, Zhang C, Ma Y Abstract Pre‑eclampsia is a common complication during pregnancy, characterized by hypertension and proteinuria. The pathogenesis of pre‑eclampsia is not fully understood. Studies on the maternal spiral artery have led scientists to consider that the ineffective infiltration of placental trophoblast cells may be a primary cause of pre‑eclampsia. The present study aimed to investigate t...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Chronic hypertension and associated cardiovascular disease are among the leading causes of maternal and perinatal morbidity and mortality in the United States. Chronic hypertension in pregnancy is associated with a host of adverse outcomes, including preeclampsia, cesarean delivery, cerebrovascular accidents, fetal growth restriction, preterm birth, and maternal and perinatal mortality. There are several key issues related to the diagnosis and management of chronic hypertension in pregnancy where data are limited and further research is needed.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Expert Review Source Type: research
This article on the new European Society of Cardiology (ESC) guidelines for diagnostics and management of acute pulmonary embolism (PE) focusses on new or changed recommendations compared to the previous version of the guidelines from 2014. The current risk-adjusted management algorithm for acute PE includes the clinical severity, aggravating comorbid conditions and right ventricular dysfunction. For low-risk patients early discharge and outpatient treatment are possible, whereas for high-risk patients reperfusion treatment and hemodynamic support have to be considered, depending on the hemodynamic situation and contraindi...
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
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