Urban environment and psychiatric disorders: a review of the neuroscience and biology

Most of the world's population now lives in cities. While living in cities have both health risks and benefits, mental health has been usually considered to be negatively affected by urbanicity. While mental health disorders have complex etiology and multiple causes, it has been shown in multiple observational studies that mood and anxiety disorders are more prevalent in urban centers and incidence has been increasing. In addition, the incidence of schizophrenia is strongly increased in people born and raised in cities.
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research

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We all have an idea in our heads of what a mass shooter looks like. But how accurate is it? Does anyone actually know? Who would you trust to find out? Is there any data on this? Well, now there is. The National Council on Behavioral Health has recently completed a comprehensive report, “Mass Violence in America: Causes, Impacts, and Solutions.” Listen in as our host interviews the medical director of the National Council for an in-depth explanation of what this exhaustive document has revealed. SUBSCRIBE &REVIEW Guest information for ‘National Council on Behavioral Health’ Podcast Episode D...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anger Brain and Behavior Interview Mental Health and Wellness Podcast Policy and Advocacy Psychiatry Psychology Research The Psych Central Show Violence and Aggression Source Type: blogs
What exactly is psychosis? What happens in the brain of a person with schizophrenia who is hallucinating? Schizophrenic Rachel Star Withers shares her personal hallucinations and delusions and Dr. Joseph Goldberg, who specializes in researching what goes on in the brain when someone is experiencing psychosis, joins to break down how the brain functions during psychotic episodes. Host Rachel Star Withers, a diagnosed schizophrenic, and co-host Gabe Howard delve into these intense subjects in this episode of Inside Schizophrenia.  Highlights from “Psychosis in Schizophrenia” Episode [02:13]  Rachel, do...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Brain and Behavior Disorders General Inside Schizophrenia Mental Health and Wellness Active psychosis Delusions Delusions Hallucinations Living with Schizoprenia Mental Disorder Mental Illness Psychology psychotic Psychotic Break Source Type: blogs
Abstract Herein we describe a focused set of new arylpiperazine derivatives as potential broad-spectrum antipsychotics. The general structure contains a quinolinone-like moiety, an arylpiperazine moiety, and a five-atom linker. Among them, 7-(5-(4-(benzo[d]isothiazol-4-yl)piperazin-1-yl)pentyl)quinolin-2(1H)-one (S6) shows a promising preclinical profile. Compound S6, characterized by partial D2 R agonism, 5-HT1A R agonism, 5-HT2A R antagonism, and blockade of SERT activities, was found to decrease psychosis- and depressive-like symptoms in rodents. The polypharmacological profile of S6 could provide opportunities...
Source: ChemMedChem - Category: Chemistry Authors: Tags: ChemMedChem Source Type: research
This study examined mental health perceptions held by Chinese immigrant parents of youth. METHODS: Eighteen parents (13 female, 5 male), who identified as having children between the ages of 13 and 21 years, participated in audio-recorded interviews using five vignettes depicting depression with and without a somatic emphasis, schizophrenia with paranoid features, attenuated psychosis syndrome, and social anxiety in youth. Questions about potential causes, likely diagnosis, and health-seeking behaviors in relation to these vignettes were asked. Interviews were analyzed for themes using a deductive-inductive hybrid appr...
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
This study provides a systemic behavioral evaluation of tobacco alkaloids and further insights into the association between affective disorders and smoking incidence. PMID: 31738931 [PubMed - as supplied by publisher]
Source: European Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharmacol Source Type: research
(Bar-Ilan University) Researchers examined the relationship between psychiatric diagnoses and future incarceration by merging data from psychiatric interviews that took place in the 1980s with 30 years of follow-up data. Among other things, they found that diagnoses of substance use and antisocial personality were predictors of future incarceration but that other psychiatric diagnoses (i.e., schizophrenia, affective disorders, anxiety disorders, as well as some other psychiatric disorders) were not independent predictors.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
Conclusion: Future sham-controlled studies with large sample sizes are needed to definitively conclude on the clinical interest of mindfulness-based interventions in FEP patients and UHR individuals as well as to understand their underlying mechanisms of action.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
(Natural News) A recent study suggests that schizophrenia is often overdiagnosed in patients – when, in fact, they exhibit symptoms of anxiety. Researchers from Johns Hopkins University studied 78 patients referred to their Early Psychosis Intervention Clinic (EPIC) between February 2011 and July 2017. 54 of those 78 patients received a predetermined diagnosis of a schizophrenia spectrum disorder....
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Conclusion: Major limitations of the reviewed studies were short trial duration, small sample sizes, and the lack of control groups. Defining the potential role of DUL in the treatment of psychiatric disorders other than major depressive disorder and generalized anxiety disorder needs further randomized, placebo-controlled studies.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
We report a longitudinal behavioral study in a methylazoxymethanol acetate (MAM) rat model of schizophrenia at three different age periods: prepuberty, late-puberty and early-adulthood. MAM-treated rats showed stable hypolocomotive activity, anxiety and cognitive deficits from late-puberty to early-adulthood. Therefore we detected the metabolites changes of adult MAM-treated rats using an in vitro proton nuclear magnetic resonance (1H-NMR) method. In the MAM-treated rats, glutamate was increased in the thalamus and hypothalamus, glutamine was increased in the hippocampus and GABA was increased in the hippocampus and prefro...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
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