Systematic Review of Perioperative Use of Immunosuppressive Agents in Patients Undergoing Bariatric Surgery

Patients who qualify for bariatric surgery are increasingly experiencing comorbid conditions which often require management through the use of immunosuppressive agents, such as corticosteroids, tumor necrosis alpha factor inhibitors, or other immunomodulators, which may increase risk of infection or wound healing complications. Perioperative management of these agents in bariatric surgery is challenging due to lack of research in that patient population. With immunosuppressive agents use on the rise, the effects of these medications must be understood, the risks posed in the perioperative period, and the benefit their sustained use may have for comorbidity management.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: Review articles Source Type: research

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This study confirmed the weight control effect of chitosan in the context of high-fat diet consumption. Interestingly, chitosan increased the serum leptin level in the high-fat diet groups and increased the oral glucose tolerance in the low-fat diet groups. Chitosan reduced the chronic inflammation caused by high-fat diet consumption. Moreover, the intestinal microbiome was influenced by the chitosan intervention as the feeding time increased. Chitosan supplementation increased the anti-obesity-related species, such as Coprobacillus cateniformis and Clostridium leptum, and significantly decreased Clostridium lactatiferment...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Abstract Introduction: Metabolic syndrome (MetS) is defined as an association between diabetes, hypertension, obesity and dyslipidemia and an increased risk of cardiovascular disease. Mitral annular calcification (MAC) is associated with several cardiovascular disorders, including coronary artery disease, atrial fibrillation (AF), heart failure, ischemic stroke and increased mortality. The CHA2DS2-VASc score is used to estimate thromboembolic risk in AF. However, the association among MAC, MetS and thromboembolic risk is unknown and was evaluated in the current study. Methods: The study group consisted of 94 patients with ...
Source: Revista Brasileira de Cirurgia Cardiovascular - Category: Cardiovascular & Thoracic Surgery Source Type: research
Consuming a high-fat diet (HFD) is a risk factor for obesity and diabetes; both of these diseases are also associated with systemic inflammation, similar to HIV infection. A HFD induces intestinal dysbiosis and impairs liver function and coagulation, with a potential negative impact on HIV/SIV pathogenesis. We administered a HFD rich in saturated fats and cholesterol to nonpathogenic (African green monkeys) and pathogenic (pigtailed macaques) SIV hosts. The HFD had a negative impact on SIV disease progression in both species. Thus, increased cell-associated SIV DNA and RNA occurred in the HFD-receiving nonhuman primates, i...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
This study was performed to establish whether CNTF exerts similar effects on human white adipocytes. To this end, adipose differentiation was induced in vitro in human multipotent adipose-derived stem (hMADS) cells. CNTF receptor α (CNTFRα) expression was assessed in hMADS cells and adipocytes by qRT-PCR, Western blotting, and immunocytochemistry. After administration of human recombinant CNTF, signaling pathways and gene expression were evaluated by Western blotting and qRT-PCR. Glucose uptake was assessed by measuring 2-nitrobenzodeoxyglucose uptake with a fluorescence plate reader. Lastly, CNTF-induced anti-...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
International Journal of Obesity, Published online: 12 November 2019; doi:10.1038/s41366-019-0459-0Association of BMI category with change in children’s physical activity between ages 6 and 11 years: a longitudinal study
Source: International Journal of Obesity - Category: Eating Disorders & Weight Management Authors: Source Type: research
ConclusionThese findings provide valuable reference data that can facilitate further detailed investigations to elucidate the pathogenic mechanism of obesity-induced diabetes in mice, which can be associated with the human condition to inform new prevention and treatment strategies.
Source: Journal of Diabetes and Metabolic Disorders - Category: Endocrinology Source Type: research
We examined the relationship between baseline MetS and renal dysfunction after a 3-year evaluation based on estimated glomerul ar filtration rate (eGFRCKDEPI) using the CKD-EPI equations modified by the Japan coefficient. CKD was defined as dipstick-positive proteinuria (>  or = 1 +) or a low eGFRCKDEPI (
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
ABSTRACT To review the occurrence of pelvic, anorectal and urinary symptoms according to the nutritional status of adultwomen. Methods This is a cross-sectional study with 54 women, aged 18 to 35 years, divided into normal weight (
Source: Revista de Nutricao - Category: Nutrition Source Type: research
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