People who walk slowly at 45 have higher risks of dementia, study finds

Duke University researchers found that the same people who were already walking slowly at age 45 looked older, had early signs of dementia, and had scored lower on mental tests at age three.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Publication date: Available online 5 October 2019Source: NeuroImageAuthor(s): AmanPreet Badhwar, Yannik Collin-Verreault, Pierre Orban, Sebastian Urchs, Isabelle Chouinard, Jacob Vogel, Olivier Potvin, Simon Duchesne, Pierre BellecAbstractStudies using resting-state functional magnetic resonance imaging (rsfMRI) are increasingly collecting data at multiple sites in order to speed up recruitment or increase sample size. The main objective of this study was to assess the long-term consistency of rsfMRI connectivity maps derived at multiple sites and vendors using the Canadian Dementia Imaging Protocol (CDIP, www.cdip-pcid.ca...
Source: NeuroImage - Category: Neuroscience Source Type: research
Conclusions: Hungarian GPs were aware of the benefits of early recognition, but the shortage of consultation time in primary care was found to be a major constraint on efficient case-finding. PMID: 31601132 [PubMed - as supplied by publisher]
Source: European Journal of General Practice - Category: Primary Care Tags: Eur J Gen Pract Source Type: research
We examined the influence of enrollment factors demonstrated to differ by race on incident mild cognitive impairment and dementia using Alzheimer's Disease Center data. METHODS: Differences in rates of incident impairment between non-Latino Whites and Blacks (n = 12,242) were examined with age-at-progression survival models. Models included race, sex, education, source of recruitment, health factors, and family history of dementia. RESULTS: No significant race differences in progression were observed in cognitively unimpaired participants. In those with mild cognitive impairment at baseline, Whites eviden...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Publication date: Available online 11 October 2019Source: Life SciencesAuthor(s): Qinqing Li, Feifei Xu, Qi Zhang, Xiaoqing Li, Meitong Guo, Yiming Zhang, Zilin Wang, Jie Wang, Jiaqi Zhao, Yajuan Tian, Zhao Zhang, Shifeng Chu, Wenbin HeAbstractAimsLearning and memory impairment is a common symptom in the early stages of various types of dementia. It is likely to reduce the incidence of dementia with correct intervention. α-Asarone is the main bioactive substance isolated from Acorus tatarinowii Schott and has been proven to improve memory dysfunction; however, at present, the specific underlying mechanism is poorly u...
Source: Life Sciences - Category: Biology Source Type: research
Discussions with Elders about Housing 
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
Publication date: Available online 12 October 2019Source: Social Science &MedicineAuthor(s): Hollin GregoryAbstractThis paper examines the entanglement of medicine, brain injury, and subjectivity within newspaper discourse and through the case of ex-American footballer Aaron Hernandez. In 2017, two years after being found guilty of murder and five years after scoring in the Super Bowl, Aaron Hernandez died by suicide in his prison cell. Hernandez was posthumously diagnosed with Chronic Traumatic Encephalopathy (CTE), a neurodegenerative disease associated with violence, depression, and dementia-like symptoms. I examine...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
DiscussionAβ misfolding in blood plasma was a strong, specific risk prediction marker for clinical AD even many years before diagnosis in a community-based setting.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Conclusions: Sepsis was specifically associated with moderate to severe vascular brain injury as assessed by microvascular infarcts. This association was stronger for microinfarcts within the cerebral cortex, with those who experienced severe sepsis hospitalization being more than twice as likely to have evidence of moderate to severe cerebral cortical injury in adjusted analyses. Further study to identify mechanisms for the association of sepsis and microinfarcts is needed.
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Clinical Investigations Source Type: research
In this study, we established a human neuronal culture system using induced pluripotent stem cells (iPSCs) to evaluate the possible effects of natural compounds on the amyloid phenotype. Unexpectedly, we found that combinational treatment of carotenoids, but not docosahexaenoic acid, significantly decreased Aβ secretion from iPSC-derived human cortical neurons. Importantly, the effects of the carotenoids resulted from specific inhibition of BACE1 activity and not from expression changes in APP or BACE1. Therefore, these results indicate a novel beneficial function of carotenoids in the anti-amyloidogenic processing of...
Source: Neuroscience Research - Category: Neuroscience Source Type: research
Discussions with Elders about HousingWhy Some Caregivers Might Refuse to Consider Outside HelpCareging for a Person Living with Dementia? Avoid Saying These Things 
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
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