Cartilage ablation of Sirt1 causes inhibition of growth plate chondrogenesis by hyperactivation of mTORC1 signaling.

In conclusion, our findings suggest that loss of Sirt1 may trigger mTORC1 signaling in growth plate chondrocytes and contributes to growth retardation, thus indicating that SIRT1 is an important regulator during chondrogenesis and providing new insights into the clinical potential of SIRT1 in bone development.
PMID: 31599935 [PubMed - as supplied by publisher]

Source: Endocrinology - October 9, 2019 Category: Endocrinology Authors: Jin X, Kang X, Zhao L, Xu M, Xie T, Li H, Li F, Qian Z, Ma Z, Zhang Y, Yang W, Zhang Z, Gao X, Chen Q, Sun H, Wu S Tags: Endocrinology Source Type: research