Pathogenicity of two Chinese Seneca Valley virus (SVV) strains in pigs

Publication date: November 2019Source: Microbial Pathogenesis, Volume 136Author(s): Lulu Chen, Jialong Zhang, Minmin Wang, Shuonan Pan, Chunxiao Mou, Zhenhai ChenAbstractSeneca Valley virus (SVV) has been identified as the causative agent of SVV-associated vesicular disease (SAVD). To investigate the pathogenicity of two newly isolated SVV strains (GD-S5/2018 and GD04/2017) in China, experimental infections of pigs were performed. In pig experiments, both SVV strains successfully infected all animals, evidenced by presence of virus shedding and robust protective antibody responses. SVV GD-S5/2018 infection resulted in characteristic clinical signs, and ulcerative lesions on the tongue and gums. However, SVV GD04/2017 did not cause any clinical symptoms except depression in pigs during the experiment. Taken together, these results demonstrate that SVV GD-S5/2018 is a virulent strain for pigs, whereas SVV GD04/2017 is nearly avirulent. The established animal models for SVV infection will be utilized to dissect the immunity and pathogenesis, and develop vaccines and antivirals.
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research

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Publication date: Available online 23 August 2019Source: Microbial PathogenesisAuthor(s): Lulu Chen, Jialong Zhang, Minmin Wang, Shuonan Pan, Chunxiao Mou, Zhenhai ChenAbstractSeneca Valley virus (SVV) has been identified as the causative agent of SVV-associated vesicular disease (SAVD). To investigate the pathogenicity of two newly isolated SVV strains (GD-S5/2018 and GD04/2017) in China, experimental infections of mice and pigs were performed. SVV GD-S5/2018 was lethal to mice infected by intramuscular, intraperitoneal, or oral routes, while SVV GD04/2017 was avirulent without causing any discernible clinical signs in mi...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
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Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
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Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
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