No Superiority of Tacrolimus Suppositories vs Beclomethasone Suppositories in a Randomized Trial of Patients With Refractory Ulcerative Proctitis

Ulcerative proctitis (UP) refractory to 5-aminosalicylic acid (5-ASA) suppositories is a challenge to treat, often requiring step up to immunomodulator or biological therapy. Topical tacrolimus is effective and safe in patients with refractory UP. However, it is not clear how tacrolimus suppositories fit into in the treatment algorithm of UP.

Source: Clinical Gastroenterology and Hepatology - October 10, 2019 Category: Gastroenterology Authors: M.R.K.L. Lie, J.E. Kreijne, G. Dijkstra, M. L öwenberg, G. van Assche, R.L. West, D. van Noord, A.E. van der Meulen - de Jong, B. Oldenburg, R.J. Zaal, B.E. Hansen, A.C. de Vries, C.J. van der Woude, Dutch Initiative on Crohn and Colitis (ICC) Source Type: research