Advances in the treatment of gastric cancer: 2019

Purpose of review The aim of this study was to review studies published within the past year regarding management of gastric cancer. Recent findings Laparoscopic gastrectomy achieves equivalent survival compared with open gastrectomy in early stage and locally advanced gastric cancer. Adjuvant chemotherapy with 6 months of S-1 and oxaliplatin was superior to 12 months of S-1, and the addition of postoperative radiation therapy did not improve survival. The FLOT regimen is the new standard for preoperative chemotherapy. In metastatic gastric cancer, the addition of docetaxel to S-1 and cisplatin failed to improve overall survival over two-drug chemotherapy. The addition of the immune checkpoint inhibitor pembrolizumab to chemotherapy failed to improve overall survival compared with chemotherapy alone. Summary Laparoscopic gastrectomy is acceptable in early and locally advanced gastric cancer. Combination adjuvant chemotherapy is superior to S-1 monotherapy. Adjuvant radiation therapy after D2 gastrectomy for node-positive gastric cancer does not improve survival. Preoperative chemotherapy with FLOT (5-FU, leucovorin, oxaliplatin and docetaxel) without radiation therapy is the standard treatment in the West. Two-drug chemotherapy is the optimal initial treatment in metastatic disease. Adding pembrolizumab to front-line chemotherapy did not improve survival, with use of immune checkpoint inhibitors reserved to treat chemotherapy refractory metastatic disease.
Source: Current Opinion in Gastroenterology - Category: Gastroenterology Tags: STOMACH AND DUODENUM: Edited by Mitchell L. Schubert Source Type: research

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Authors: Yang JD, Ma L, Zhu Z Abstract We assessed the expression of Serpin Family E Member 1 (SERPINE1) and its prognostic values in gastric adenocarcinoma (GAC) by using the data from TCGA database. The biological functions of SERPINE1 in GAC cells were detected by cell counting Kit-8, colony-forming, Transwell, and wound-healing assays, appropriately. Relative mRNA and protein levels were detected by RT-qPCR and western blot. Bioinformatics analysis indicated that SERPINE1 was significantly up-regulated in GAC tissues compared to normal tissues. High SERPINE1 expression led to a short overall survival and could ...
Source: Journal of Chemotherapy - Category: Cancer & Oncology Tags: J Chemother Source Type: research
The FDA approved a new antibiotic to treat superbug linked to stomach cancer and ulcers.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
Authors: Zhang Y, Tang M, Wang XG, Gu JH, Zhou LN, Jin J, Li P, Wang LQ, Chen MB Abstract BACKGROUND: interleukin-37 (IL-37) is as a natural suppressor of the innate inflammatory and immune responses. It has also been reported to be involved in carcinogenesis and metastasis. The present case-control study was designed to investigate the role of serum levels of IL-37 in patients with gastric cancer. METHODS: serum IL-37 levels were determined using the enzyme-linked immunosorbent assay in 180 patients diagnosed with gastric cancer and 100 healthy controls. The association between IL-37 levels and clinical factor...
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
Emily LeFrancq, 22, of Woodland, Washington, was diagnosed with a mutation, which put her at a high risk of a rare syndrome that can develop into diffuse gastric cancer.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Condition:   Quality of Life Intervention:   Procedure: lappg Sponsors:   RenJi Hospital;   The First Affiliated Hospital of Dalian Medical University;   Affiliated Hospital of Qinghai University;   Zhejiang Cancer Hospital;   Second Affiliated Hospital of Suzhou University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Gastric Adenocarcinoma;   GastroEsophageal Cancer Interventions:   Drug: Cabozantinib;   Drug: Pembrolizumab Sponsors:   University of California, Irvine;   Exelixis Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Quality of Life Intervention:   Procedure: lappg Sponsors:   RenJi Hospital;   The First Affiliated Hospital of Dalian Medical University;   Affiliated Hospital of Qinghai University;   Zhejiang Cancer Hospital;   Second Affiliated Hospital of Suzhou University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Gastric Adenocarcinoma;   GastroEsophageal Cancer Interventions:   Drug: Cabozantinib;   Drug: Pembrolizumab Sponsors:   University of California, Irvine;   Exelixis Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The aim of this study was to explore the prognostic factors and establish a nomogram to predict the long-term survival of gastric cancer patients.
Source: BMC Gastroenterology - Category: Gastroenterology Authors: Tags: Research article Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
More News: Cancer | Cancer & Oncology | Chemotherapy | Docetaxel | Eloxatin | Gastrectomy | Gastric (Stomach) Cancer | Gastroenterology | Laparoscopy | Radiation Therapy | Study | Taxotere