Etidronate halts systemic arterial calcification in pseudoxanthoma elasticum

In pseudoxanthoma elasticum (PXE), low levels of inorganic pyrophosphate result in extensive arterial calcification. Recently, the treatment of ectopic mineralization in the PXE (TEMP) trial showed that one year of treatment with etidronate halts progression of femoral artery calcification in PXE patients. The aim of this study was to test the efficacy of etidronate on calcification in different vascular beds.

Source: Atherosclerosis - October 10, 2019 Category: Cardiology Authors: Jonas W. Bartstra, Pim A. de Jong, Guido Kranenburg, Jelmer M. Wolterink, Ivana Isgum, Alayna Wijsman, Bas Wolf, Annemarie M. den Harder, Willem P. Th M. Mali, Wilko Spiering Source Type: research