Evaluating improvements in cardiac dosimetry in breast radiotherapy and comparison of cardiac sparing techniques

AbstractPurpose/objective(s)Data from Darby et al. demonstrated that cardiac dose in patients undergoing breast radiation therapy is associated with cardiac events. Cardiac dose is primarily dependent on treatment laterality and treatment fields. More recently, techniques such deep inspiratory breath hold (DIBH) and prone positioning have been used as cardiac sparing techniques. The purpose of this study is to assess changes in cardiac dosimetry with cardiac sparing techniques.Materials/methodsThis retrospective study included breast cancer patients treated from 2010 to 2018 at a single institution. Mean heart dose (MHD) was analyzed with respect to treatment era, laterality, cardiac sparing technique, and treatment fields, including regional nodal irradiation (RNI) and internal mammary nodal irradiation (IMNI).ResultsSeven hundred sixty-five patients were included in this study. Average MHD was 1.87  Gy for left-sided cases and 0.71 Gy for right-sided cases (p 
Source: Journal of Radiation Oncology - Category: Cancer & Oncology Source Type: research

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Prostate cancer is the most prevalent form of cancer among all men in the United States (US). It is also the second leading cause of cancer-related deaths in the US among men, largely due to the progressively treatment resistant nature of the disease. Treatment options for early stage prostate cancer include watchful waiting, radical prostatectomy, radiation therapy, and importantly androgen-deprivation therapy (ADT). Prostate cancer is dependent on androgen hormones, such as testosterone, for sustaining and promoting growth. Androgen hormones bind to the Androgen receptor (AR), causing AR localization to the nucleus where...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research
Randomized controlled trials have failed to report any survival advantage for WBRT combined with SRS in the management of brain metastases, despite the enhanced local and distant control in comparison to each treatment alone. Literature review have revealed important role of primary histology of the tumor when dealing with brain metastases. NSCLC responds better to combined approach even when there was only single brain metastasis present while breast cancer has registered better survival with SRS alone probably due to better response of primary tumor to advancement in surgical and chemotherapeutic agents. Furthermore, mut...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Abstract To evaluate the clinical feasibility and dosimetric benefits of a novel gantry-static couch-motion (GsCM) technique for external beam photon boost treatment of lumpectomy cavity in patients with early-stage breast cancer in comparison to three-dimensional conformal radiotherapy (3D-CRT), wedge pair in supine position (WPS), and wedge pair in decubitus position (WPD) techniques. A retrospective review was conducted on breast patients (right breast, n = 10 and left breast, n = 10) who received 10 Gy boost after 50 Gy to whole breast. The treatment plans were generated using an ...
Source: Clinical Genitourinary Cancer - Category: Cancer & Oncology Authors: Tags: J Appl Clin Med Phys Source Type: research
PMID: 32631621 [PubMed - as supplied by publisher]
Source: Asian Journal of Surgery - Category: Surgery Authors: Tags: Asian J Surg Source Type: research
CONCLUSIONS: It is important to consult a soft tissue oncologist for tumors in the breast and perform appropriate examination and treatment if soft tissue tumors cannot be ruled out. PMID: 32602101 [PubMed - in process]
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: Tokai J Exp Clin Med Source Type: research
CONCLUSIONS: The AeroForm creates significant dose uncertainties in the chest wall-metal interface. The AcurosXB dose calculation algorithm is recommended for more accurate calculations. If possible, post-mastectomy radiation therapy should be delivered after the permanent implant is in place. PMID: 32614518 [PubMed - as supplied by publisher]
Source: Clinical Genitourinary Cancer - Category: Cancer & Oncology Authors: Tags: J Appl Clin Med Phys Source Type: research
This study evaluated the characteristics and care patterns for MBC compared with female breast cancer (FBC) in Japan.MethodsUsing the National Database of Hospital ‐Based Cancer Registries (HBCR) linked to the Diagnosis Procedure Combination data, we analyzed newly diagnosed breast cancer cases between January 2012 and December 2015 at participating hospitals in a large quality‐of‐care monitoring project. We employed logistic regression models to assess cancer treatment differences between MBC and FBC in patients who were indicated for adjuvant radiation therapy and neo‐adjuvant/adjuvant chemotherapy.ResultsOf 142,...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Liz Satterfield has a ritual for every time she returns home after leaving the house. Diagnosed with metastatic breast cancer in 2016, the Kirkland, Washington resident recently learned that the cancer that had spread to her brain in 2018 was still growing. Throughout the pandemic, she’s had to visit the hospital at least once every three weeks, often more frequently, for treatments to control her disease. “I have a pair of shoes in a paper bag that I keep in the trunk of my car or a rack in the garage. I only wear those shoes when I’m going in to get treatment,” she says. “When I come home, I...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Source Type: news
A previously healthy 36-year-old premenopausal woman with no known family history of breast cancer presented with palpable nodules in her left breast. Diagnostic mammogram and ultrasound demonstrated an 8 × 4 cm area of segmental pleomorphic calcifications with scattered masses in the left breast at 7 to 8 o’clock. A biopsy of the anterior and posterior left breast lesions showed an invasive ductal carcinoma. Intermediate nuclear grade estrogen and progesterone receptors stained positive (>90%), and human epidermal growth factor receptor 2 (HER2) was equivocal by fluorescence in situ hybridization.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research
Conditions:   Anatomic Stage I Breast Cancer AJCC v8;   Anatomic Stage IA Breast Cancer AJCC v8;   Anatomic Stage IB Breast Cancer AJCC v8;   Anatomic Stage II Breast Cancer AJCC v8;   Anatomic Stage IIA Breast Cancer AJCC v8;   Anatomic Stage IIB Breast Cancer AJCC v8 ;   Anatomic Stage III Breast Cancer AJCC v8;   Anatomic Stage IIIA Breast Cancer AJC...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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