Metformin abrogates age-associated ovarian fibrosis.

CONCLUSIONS: These data support a novel hypothesis that unifies the primary non-hereditary ovarian cancer risk factors through the development of ovarian fibrosis and the formation of a pre-metastatic niche, and suggests a potential use for metformin in ovarian cancer prophylaxis.
PMID: 31597663 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - October 8, 2019 Category: Cancer & Oncology Authors: McCloskey CW, Cook DP, Kelly BS, Azzi F, Allen CH, Forsyth-Greig A, Upham J, Rayner KJ, Gray DA, Boyd RW, Murugkar S, Lo B, Trudel D, Senterman MK, Vanderhyden BC Tags: Clin Cancer Res Source Type: research