Hyperinsulinaemia promotes Her2 breast cancer metastasis

Epidemiological studies have associated both type 2 diabetes and hyperinsulinaemia with breast cancer in women. The Her2 oncogene is associated with metastasis and poor outcome. Ferguson and colleagues used a mouse model of Her2-mediated breast cancer to demonstrate that hyperinsulinaemia results in larger, more aggressive primary tumours, with more numerous lung metastases. Read the full article in Ferguson et al (2013) Endocrine-Related Cancer 20 391—401, DOI: 10.1530/ERC-12-0333.
Source: Society for Endocrinology - Category: Endocrinology Source Type: news