Development and validation of a clinical model to predict intraoperative hemodynamic instability in patients with pheochromocytomas surgery.

Development and validation of a clinical model to predict intraoperative hemodynamic instability in patients with pheochromocytomas surgery. Endocr J. 2019 Oct 10;: Authors: Bai S, Wu B, Yao Z, Zhu X, Jiang Y, Wang H Abstract Although currently the primary strategy for the treatment of pheochromocytomas is surgery, it is associated with a high risk of intraoperative hemodynamic instability (IHD), even with adequate preoperative medical preparation, which may result in life-threatening situations. The aim of this study was to develop and validate a nomogram for preoperative prediction of IHD related to pheochromocytoma surgery. The development cohort consisted of 283 patients with pheochromocytoma who underwent unilateral laparoscopic or open adrenaletomy at our center between January 1, 2007 and December 31, 2016. The clinicopathological characteristics of each patient were recorded. The least absolute shrinkage and selection operator binary logistic regression model was used for data dimension reduction and feature selection, while multivariable logistic regression analysis was used to develop the prediction model. An independent cohort consisting of 119 consecutive patients from January 1, 2017 to December 31, 2018 was used for validation. The performance of the prediction model was assessed in regards to discrimination, calibration, and clinical usefulness. The predictors of this model included body mass index, coronary heart dise...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research