Overexpression of receptor PURPL and downregulation of NONHSAT062994 as potential biomarkers in gastric cancer

Publication date: Available online 10 October 2019Source: Life SciencesAuthor(s): Heresh Moridi, Jamshid Karimi, Heidar Tavilani, Iraj Khodadadi, Amir Nader Emami RazaviAbstractAimsLong non-coding RNAs (LncRNAs) play central roles in the formation and development of gastric cancer (GC). The aim of this study was to evaluate the expression of PURPL and NONHSAT062994 and the relationship between their expressions with clinical characteristics in GC.Main methodsPURPL and NONHSAT062994 LncRNAs and p53 gene expression levels were analyzed both in 50 pairs of cancerous and adjacent noncancerous tissue samples in GC patients using qRT-PCR and in four sets of data obtained from Gene Expression Omnibus (GEO) database. Chi-square (χ2) test was used to determine the relationship between PURPL, NONHSAT062994 RNA levels and the clinicopathological characteristics of GC. Receiver operating characteristic (ROC) curves were drawn to represent sensitivity and specificity of PURPL and NONHSAT062994 expression as markers of GC.Key findingsExpression of PURPL was significantly upregulated in 50 GC samples as well as in GC tissues from GSE13911 and GSE27342 datasets. Our results demonstrated that PURPL RNA level in GC was significantly related to tumor size and histopathological grade. p53 expression at both protein and mRNA levels were significantly decreased in GC tissues compared to adjacent control samples.NONHSAT062994 expression was downregulated in 50-pair GC and GC tissues from GSE1...
Source: Life Sciences - Category: Biology Source Type: research

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Source: Journal of Chemotherapy - Category: Cancer & Oncology Tags: J Chemother Source Type: research
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Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
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Condition:   Quality of Life Intervention:   Procedure: lappg Sponsors:   RenJi Hospital;   The First Affiliated Hospital of Dalian Medical University;   Affiliated Hospital of Qinghai University;   Zhejiang Cancer Hospital;   Second Affiliated Hospital of Suzhou University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Gastric Adenocarcinoma;   GastroEsophageal Cancer Interventions:   Drug: Cabozantinib;   Drug: Pembrolizumab Sponsors:   University of California, Irvine;   Exelixis Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Quality of Life Intervention:   Procedure: lappg Sponsors:   RenJi Hospital;   The First Affiliated Hospital of Dalian Medical University;   Affiliated Hospital of Qinghai University;   Zhejiang Cancer Hospital;   Second Affiliated Hospital of Suzhou University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Gastric Adenocarcinoma;   GastroEsophageal Cancer Interventions:   Drug: Cabozantinib;   Drug: Pembrolizumab Sponsors:   University of California, Irvine;   Exelixis Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: BMC Gastroenterology - Category: Gastroenterology Authors: Tags: Research article Source Type: research
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