MicroRNA-145 promotes the epithelial-mesenchymal transition in peritoneal dialysis-associated fibrosis by suppressing fibroblast growth factor 10 [Molecular Bases of Disease]
In conclusion, miR-145 promotes the EMT during the development of peritoneal fibrosis by suppressing FGF10 activity, suggesting that miR-145 represents a potential therapeutic target for managing peritoneal fibrosis.
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Jiayu Wu, Qianyin Huang, Peilin Li, Yuxian Wang, Chenghao Zheng, Xianghong Lei, Shuting Li, Wangqiu Gong, Bohui Yin, Congwei Luo, Jing Xiao, Weidong Zhou, Zhaozhong Xu, Yihua Chen, Fenfen Peng, Haibo Long Tags: Molecular Bases of Disease Source Type: research