Identification of Biomarkers in Neuropsychiatric Disorders Based on Systems Biology and Epigenetics

This article suggests that systems biology, emphasizing the epigenetic component of systems biology, could help identify clinically useful biomarkers in neuropsychiatric disorders like SZ, BD, and MDD.
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research

Related Links:

Publication date: Available online 14 November 2019Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): S. Gentile, F. Strollo, E. Satta, T. Della-Corte, C. Romano, G. Guarino, Nefrocenter Research Study Group: Nephrologists, Diabetologists, NursesSummaryDiabetes Mellitus (DM) is the most common cause of renal failure and ESRD all over the world, and often requires an individualized insulin treatment regimen. Malnutrition, depression-related eating behavior changes, high on-off-dialysis day-to-day glycemic variability and frequent hypoglycemic events occurring during or immediately after dialy...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Publication date: Available online 14 November 2019Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Mahdieh Sedighi Pashaki, Jamal Asad Mezel, Zahra Mokhtari, Reza Ghanei Gheshlagh, Parisa Shahbazi Hesabi, Taban Nematifard, Soore KhakiAbstractDepression is one of the most common psychiatric disorders in patients with diabetes, which can exacerbate and accelerate adverse diabetes complaints by reducing self-care behaviors and medication adherence. The purpose of this study is to estimate the prevalence of depression in Iranian patients with diabetes. The search was conducted in the database...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
In this study, we have used a novel DNAzyme based approach to create a larval model of FXS in zebrafish with specific focus on the early developmental window.MethodsFmr1specific DNAzymes were electroporated into embryos to create theknockdown. Changes in RNA and protein levels of FMRP and relevant biomarkers were measured in the 0-7dpf window. Behavioral tests to measure anxiety, cognitive impairments and irritability in the larvae were conducted at the 7dpf stage. Drug treatment was carried out at various time points in the 0-7dpf window to identify the critical window for pharmacological intervention.ResultsThe DNAzyme b...
Source: Journal of Pharmacological and Toxicological Methods - Category: Drugs & Pharmacology Source Type: research
This study aimed to investigate the risk behaviors of adolescents with T1D and the effect of orthorexic eating behaviors (OEB) on glycemic control (GC). Methods: This cross-sectional study was conducted with 107 adolescents with T1D who were between 13-18 years of age and attended high school. The risk behavior scale (RBS) and orthorexic behavior scale (ORTO-11) were administered to the participants. A high RBS score indicates risky behavior; a low ORTO-11 score suggests a tendency to OEB. At the same time, participants were tested for GC and categorized as optimal GC (HbA1c ≤7%) or poor GC (HbA1c>7%). Result...
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research
ConclusionesLos resultados indican que los síntomas negativos y el funcionamiento premórbido predicen directamente la funcionalidad, mientras que los factores cognitivos muestran interacciones más complejas con los síntomas negativos y la funcionalidad. Estos resultados deberían ser considerados para nuevas estrategias de intervención.AbstractIntroductionAlthough it is well-known that several factors such as symptoms and cognition are related with functional outcome in schizophrenia, the complex nature of the disorder makes necessary to study their interaction by means of a more an...
Source: Revista de Psiquiatria y Salud Mental - Category: Psychiatry Source Type: research
ConclusionOur results highlight rumination as a two-edged sword that reflects a disease-specific neuropathology but also points to a functionality of depressive symptoms with evolutionary meaning.
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
ConclusionsThese findings provided only modest support for the temporal dynamics of positive emotion conceptualization because they revealed no evidence for: 1) specific anticipatory pleasure deficits in schizophrenia-spectrum participants compared to controls; 2) significant reductions in anticipatory pleasure relative to consummatory pleasure in schizophrenia-spectrum participants.
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Publication date: December 2019Source: Neuroscience &Biobehavioral Reviews, Volume 107Author(s): Sean P. Carruthers, Tamsyn E. Van Rheenen, Caroline Gurvich, Philip J. Sumner, Susan L. RossellAbstractThe aim of the present review was to systematically summarise our current understanding of the structure of the cognitive heterogeneity that exists within schizophrenia spectrum disorder (SSD). Fifty-two relevant studies were identified from January 1980 to March 2019 that investigated cognitive subgroups within SSD. Twenty-five studies employed classification criteria based on current neuropsychological function, 14 stu...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
Insomnia can be a disruptive condition that affects your entire life. When you aren’t able to sleep at night, it can negatively impact issues in almost every area of your life and well-being. If you are taking sleeping pills or are thinking about starting to take sleeping pills, make sure you know as much as possible about all the sleeping pill side effects. What Are Sleeping Pills and How Do They Work? Sleeping pills are used to treat insomnia. According to the National Sleep Foundation, insomnia is described as difficulty falling asleep or staying asleep, even when a person has the chance to do so. People with ins...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction to Pharmaceuticals Sleep healthy sleep insomnia sleep aids sleep and chronobiology laboratory sleep deprivation sleep disorder treatment sleep disorders sleep duration sleep habits sleeping sleeping pills sleeplessness Source Type: blogs
Adding a single infusion of ketamine to a program of mindfulness-based relapse prevention (MBRP) may promote abstinence in patients who use cocaine, according to a study published in the NovemberAmerican Journal of Psychiatry.In a five-week trial conducted by Elias Dakwar, M.D., of Columbia University Medical Center and colleagues, 55 patients who met theDSM-IV criteria for cocaine dependence were randomized to receive a 40-minute intravenous infusion of either ketamine or midazolam (a preoperative sedative). They received their infusions on the second day of a five-day hospitalization in a psychiatric research unit. Durin...
Source: Psychiatr News - Category: Psychiatry Tags: abstinence cocaine dependence Elias Dakwar ketamine M.D. midazolam mindfulness-based relapse prevention Source Type: research
More News: Biology | Bipolar | Brain | Depression | Fragile X Syndrome | Genetics | Mania | Neurology | Rett Syndrome | Schizophrenia