Acute tubulointerstitial nephritis and IgM deposits on glomerular capillary walls after immunotherapy with nivolumab for metastatic renal cell carcinoma

AbstractNivolumab is an anti-programmed cell death-1 antibody that is utilized as an immune checkpoint inhibitor for several malignancies. However, this agent is associated with immune-related adverse events (irAEs), mainly in the spectrum of autoimmune disease including interstitial pneumonia, colitis, type 1 diabetes, and renal impairment. We herein present the case of a 59-year-old man with renal cell carcinoma who developed worsening renal function approximately 4  months after initiation of nivolumab. Urinalysis showed proteinuria and microscopic hematuria along with increase levels ofN-acetyl- β-d-glucosaminidase. Renal biopsy revealed acute tubulointerstitial nephritis and thickening of the glomerular basement membranes. Immunofluorescence showed granular IgM deposits in capillary loops. We initiated high-dose prednisolone therapy with nivolumab, which improved renal function and achieved complete remission of proteinuria. Although renal irAEs are considered to be rare and glomerulonephropathy is not typical presentation, physicians need the close monitoring of renal function and urinalysis in patients under immunotherapy with this agents. In addition, our case provides a possible link between nivolumab and immune-mediated glomerulonephropathy.
Source: CEN Case Reports - Category: Urology & Nephrology Source Type: research

Related Links:

Publication date: Available online 24 September 2020Source: Journal of Theoretical BiologyAuthor(s): Roberta Coletti, Andrea Pugliese, Luca Marchetti
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
Publication date: Available online 24 September 2020Source: Microvascular ResearchAuthor(s): Lauren Van Hove, Kirsten R. Kim, Denise M. Arrick, William G. Mayhan
Source: Microvascular Research - Category: Biochemistry Source Type: research
Publication date: November 2020Source: Urology Case Reports, Volume 33Author(s): Shoaib Safiullah, Shivesh Kabra, Taha Anwar, Maryna Vazmitsel, Katsiaryna Laziuk, Naveen Pokala
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Publication date: Available online 25 September 2020Source: Actas Urológicas Españolas (English Edition)Author(s): L. Polanco Pujol, F. Herranz Amo, J. Caño Velasco, M. Moralejo Garate, D. Subirá Rios, G. Barbas Bernardos, J. Mayor de Castro, J. Aragón Chamizo, A. Husilllos Alonso, C. Hernández Fernández
Source: Actas Urologicas Espanolas - Category: Urology & Nephrology Source Type: research
Publication date: Available online 24 September 2020Source: European UrologyAuthor(s): David D’Andrea, Benjamin Pradere, Shahrokh F. Shariat
Source: European Urology - Category: Urology & Nephrology Source Type: research
Authors: Li L, Sun W, Han M, Ying Y, Wang Q Abstract BACKGROUND Early and rapid identification of severe coronavirus disease 2019 (COVID-19) cases is important. The present study aimed to investigate the predictors of disease severity and thus determine the trends for disease progression early. MATERIAL AND METHODS Patients with COVID-19 were recruited from Fuyang Second People's Hospital from January to February 2020. Patients' demographic, epidemiological, and clinical data were collected, and the relationships between these variables and disease severity were analyzed. RESULTS A total of 158 cases were included ...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Publication date: Available online 24 September 2020Source: International Journal of Surgery Case ReportsAuthor(s): Christina Krogerus, Matilda Svenning, Anette Andersen Pilt, Hannah Trøstrup
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Publication date: Available online 24 September 2020Source: Respiratory Medicine Case ReportsAuthor(s): Tsuyoshi Shirai, Takahiro Mitsumura, Kei Aoyagi, Tsukasa Okamoto, Moe Kimura, Taku Gemma, Takaaki Shigematsu, Junichi Takahashi, Seishin Azuma, Riku Yoshizuka, Hirokazu Sasaki, Nao Urushibata, Kanae Ochiai, Kenichi Hondo, Koji Morishita, Junichi Aiboshi, Yasuhiro Otomo, Yasunari Miyazaki
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Background: The Japan Society for Respiratory Endoscopy performed a nationwide survey to evaluate the current status and complications of bronchoscopy. Data on deaths due to bronchoscopy, complications after bronchoscopy, and particularly, complications of forceps biopsy were surveyed. Methods: The survey form was mailed to 532 facilities accredited by the society. The numbers of procedures, complications, and deaths were investigated. Results: The response rate was 79.1% (421 facilities). Deaths attributable to diagnostic bronchoscopy occurred in 11 (0.011%) of 98,497 cases. In regards to forceps biopsy, the guid...
Source: Journal of Bronchology and Interventional Pulmonology - Category: Respiratory Medicine Tags: Original Investigations Source Type: research
Conditions:   Covid19;   Pneumonia Interventions:   Drug: NuSepin® 0.1 mg;   Drug: NuSepin® 0.2 mg;   Drug: Placebo Sponsor:   Shaperon Recruiting
Source: - Category: Research Source Type: clinical trials
More News: Autoimmune Disease | Cancer & Oncology | Carcinoma | Diabetes | Diabetes Type 1 | Endocrinology | Immunotherapy | Kidney Cancer | Nephritis | Pneumonia | Prednisolone | Proteinuria | Renal Cell Carcinoma | Urology & Nephrology