Endobronchial Ultrasound-Guided Transbronchial Needle-Aspiration With Suction in Obtaining Samples From Patients With Suspected Nodal Metastatic Lung Cancer

Condition:   Lung Carcinoma Interventions:   Procedure: Bronchoscopy;   Procedure: Ultrasound-Guided Transbronchial Needle Aspiration Sponsors:   Ohio State University Comprehensive Cancer Center;   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Introduction: The EBUS-TBNA is a minimally invasive technique widely used in the diagnosis, staging and immunohistochemistry analysis of lung cancer.1PDL-1 is a checkpoint on NSCLC that can be targeted with immunotherapy.2Routine PDL-1 testing was introduced at Oxford University Hospital NHS Foundation Trust (OUHFT) in 2017 and it is unclear if EBUS-TBNA provides adequate tissue for testing. In our current practice at the OUHFT, all NSCLC cases (Squamous Cell Lung Carcinoma and Lung Adenocarcinoma) identified on cytopathology are subsequently tested for PDL-1 tumour percentage score (TPS). The aim of this study was to see ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung cancer Source Type: research
Endoscopic ultrasound (with bronchoscope) fine needle aspiration (EUS-B-FNA) has been recognized as a useful and safe technique in sampling mediastinal lymph nodes. Few data are available on its accuracy in diagnosing pulmonary parenchymal lesions adjacent to the esophagus.We performed an observational, retrospective study aimed to evaluate accuracy and safety of EUS-B-FNA for lung parenchymal abnormalities, in two Italian reference centers. Furthermore, impact of rapid on-site evaluation (ROSE) and lesion anatomical site (i.e. lobe) on diagnostic yield were assessed.From November 2016 to January 2018, 21 patients (52.4% m...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Interventional Pulmonology Source Type: research
Conclusion: The visual appearance of EBUS-TBNA aspirate may provide a clue to the diagnosis. This may prompt the bronchoscopist to obtain samples for ancillary investigations such as Xpert MTB/RIF in cheesy aspirates and avoid further passes from ‘black’ nodes during lung cancer staging.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Interventional Pulmonology Source Type: research
CONCLUSIONS:  EBUS-TBNA revealed a specific cause for suspected non-malignant lymphadenopathy in one-third of cases and was associated with excellent specificity. Predominant specific causes were granuloma, besides from tumor. In 3 patients pathogen could be isolated by TBNA. PMID: 29788514 [PubMed - as supplied by publisher]
Source: Pneumologie - Category: Respiratory Medicine Tags: Pneumologie Source Type: research
Conclusions: SSA is highly effective at preserving samples for molecular testing from EBUS-FNA. Therefore a single minimally invasive procedure offers access to novel immunotherapy, enhancing lung cancer care. With increasing emphasis on immunotherapy its value is likely to increase.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung Cancer Source Type: research
Conclusions: Tumor heterogeneity was noticed from spatially distinct regions from advanced primary lung cancers. The single biopsy specimens may not represent the whole landscape of genetic alteration in advanced primary lung cancers.Citation Format: Sang-Won Um, Je-Gun Joung, Su Yeon Lee, Joon Seol Bae, Jinha Park, Woong-Yang Park. Tumor heterogeneity of advanced primary lung cancer evaluated by multiregion sequencing. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Molecular and Cellular Biology Source Type: research
More News: Bronchoscopy | Cancer | Cancer & Oncology | Carcinoma | Fine Needle Aspiration | Lung Cancer | Research | Ultrasound