Sarcoidosis presenting with and without Löfgren’s syndrome: clinical, radiological and behavioral differences observed in a group of 691 patients
Publication date: Available online 11 October 2019Source: Joint Bone SpineAuthor(s): Manuel Rubio-Rivas, Jonathan Franco, Xavier CorbellaAbstractObjectives: Just a few series of Löfgren’s syndrome have been reported. Our aim was to describe the epidemiology and clinical profile of sarcoidosis patients presenting with Löfgren’s syndrome vs. non-Löfgren’s syndrome.Methods: Retrospective cohort study of 691 consecutive patients with sarcoidosis diagnosed at the Bellvitge University Hospital in Barcelona, Spain, between 1976 and 2018.Results: 309 patients (44.7%) were diagnosed with Löfgren’s syndrome and 382 with non-Löfgren’s syndrome (55.3%). The mean age at diagnosis was 39.8 years-old (SD 11.7) vs. 46.6 (SD 14.5) (p
This study shows a heterogenous spectrum of SAIDs with a high number of g enetically confirmed monogenic diseases; notably,LACC1 associated diseases. Hopefully, this work will be the first step for a prospective registry for SAIDs in Arab countries.
To improve diagnosis and treatment of laryngeal sarcoidosis, we present a rare case of upper airway obstruction of unclear aetiology, with life ‐threatening complication in a 19‐year‐old boy. To improve diagnosis and treatment of laryngeal sarcoidosis, we present a rare case of upper airway obstruction of unclear aetiology, with life ‐threatening complication.The patient was a 19‐year boy who presented with progressive severe dyspnoea for eight months. After extensive diagnostic evaluations with no conclusive diagnosis, biopsy showed non‐caseating granulomatous inflammation consistent with laryngeal sarc...
ConclusionsIdiopathic granulomatous hypophysitis, a rare inflammatory disease of the pituitary gland, is a diagnosis of exclusion for which both medical and surgical management are reported in the literature. We present a case of idiopathic granulomatous hypophysitis who was symptom free with no complications of hypopituitarism following its transsphenoidal resection after 9 months of follow-up.
UCLA Health has launched a $20 million fundraising initiative to create a new center for advanced lung disease at theDavid Geffen School of Medicine at UCLA. To date, the initiative has secured $4.37 million for the Lung Health Research Accelerator Fund, including three gifts of $1 million each from Michael and Linda Keston, William Pierpoint, and Jeffrey and Robin Raich, and a total of $1.37 million from nine other donors.The fund will support the work of Dr. John Belperio and Dr. Joseph Lynch III in the medical school ’s division of pulmonary and critical care medicine. Belperio’s research is focused on ident...
Kaiser et al.  make a compelling case for T-lymphocytes in the pathogenesis of sarcoidosis, particularly when considering the initiation of granulomatous inflammation and patients with acute, self-resolving sarcoidosis (Lofgren's syndrome). However, in some situations it seems that T-cells are less important. For example, SCID (severe combined immunodeficient) mice, which have no lymphocytes, develop macrophage-rich granulomas when infected with mycobacteria . In clinical practice, powerful suppression of T-lymphocytes with anti-rejection medication cannot prevent recurrence of granulomas in one third of patients who...
ConclusionTo ensure a consensus about the therapy and follow up, we have to make revisions and reorganisations on the DPLD classification which was proposed in 2007. We need a new childhood DPLD classification that will cover all these disease groups.
PMID: 31729007 [PubMed - as supplied by publisher]
This case series study measures the responsiveness of the Cutaneous Sarcoidosis Activity and Morphology Instrument to changes in disease activity over time.
ConclusionSymptoms of pyloric obstruction as a manifestation of isolated gastric Crohn ’s disease are extremely unusual in clinical practice, awareness of which would facilitate early appropriate investigations and treatment.