Xenon modulates synaptic transmission to rat hippocampal CA3 neurons at both pre- and postsynaptic sites.

In conclusion, our data indicate that a presynaptic decrease of excitatory transmission is likely to be the major mechanism by which Xe induces anaesthesia, with little contribution of effects on GABAergic synapses. This article is protected by copyright. All rights reserved. PMID: 31598974 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31598974?dopt=Abstract

Source: The Journal of Physiology - October 9, 2019 Category: Physiology Authors: Nonaka K, Kotani N, Akaike H, Shin MC, Yamaga T, Nagami H, Akaike N Tags: J Physiol Source Type: research