The fruit of the aidan tree from African medicine shows promise as a natural treatment for gout

(Natural News) People from the lowland forests of tropical Africa use the dried fruit of the aidan tree (Tetrapleura tetraptera) as a spice. In traditional medicine, they also utilize different parts of the tree for treating various diseases. A study published in the journal Food Science and Human Wellness suggests using the fruit as a functional food for preventing...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news

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Conclusions: This study demonstrated for the first time that BHA exhibits anti-inflammatory, antioxidative and antihyperuricemic effects in vivo, suggesting a potential therapeutic application of BHA in gouty arthritis and hyperuricemia. PMID: 31622116 [PubMed - in process]
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
by Xue Li, Xiangrui Meng, Yazhou He, Athina Spiliopoulou, Maria Timofeeva, Wei-Qi Wei, Aliya Gifford, Tian Yang, Tim Varley, Ioanna Tzoulaki, Peter Joshi, Joshua C. Denny, Paul Mckeigue, Harry Campbell, Evropi Theodoratou BackgroundThe role of urate in cardiovascular diseases (CVDs) has been extensively investigated in observational studies; however, the extent of any causal effect remains unclear, making it difficult to evaluate its clinical relevance. Methods and findingsA phenome-wide association study (PheWAS) together with a Bayesian analysis of tree-structured phenotypic model (TreeWAS) was performed to examine disea...
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
Condition:   Gout Interventions:   Drug: DYV700;   Other: Placebo Sponsor:   Dyve Biosciences, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Gout Interventions:   Drug: DYV700;   Other: Placebo Sponsor:   Dyve Biosciences, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Gout Interventions:   Drug: DYV700;   Other: Placebo Sponsor:   Dyve Biosciences, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSION: The relationship between gout and PPDM is bidirectional in the postpancreatitis setting. A prior history of gout is a risk factor of PPDM, particularly in women. PMID: 31615915 [PubMed - as supplied by publisher]
Source: J Rheumatol - Category: Rheumatology Authors: Tags: J Rheumatol Source Type: research
Three clinical experts on gout offer their insights into common management errors, clinical pearls, new safety data from the FDA and the role of biologic therapies in the management of gout.
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Biologics & Biosimilars Conditions Crystal Arthritis DMARDs & Immunosuppressives Drug Updates Gout Source Type: research
Condition:   Gout Intervention:   Procedure: Joint Biopsy Sponsors:   Attune Health Research, Inc.;   Horizon Pharma Ireland, Ltd., Dublin Ireland Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In this study, the toxicity of mPEG-UHC was studied in rats and monkeys over a 26-week period of repeated intravenous dosing. There were no obvious toxic reactions in the tested animals, with the exception of mPEG-UHC blood clearance and immunogenicity. After repeated injections of mPEG-UHC, rapid loss of uricolytic activity (RLA) was not detected in rats, whereas RLA was observed in 44.4% of drug-treated monkeys. In these monkeys, RLA was observed in 11.1% of males and 77.8% of females, and such incidences increased with higher dosing. High titres of anti-uricase IgG antibodies were associated with RLA but did not result ...
Source: Life Sciences - Category: Biology Source Type: research
AbstractBackgroundPeople with Alzheimer's disease (AD) often have multimorbidity and take multiple medicines. Yet few studies have examined medicine utilization for comorbidities comparing people with and without AD.ObjectiveThe aim was to investigate the patterns of medication use for comorbidities in people with and without AD.MethodsAn Australian population ‐based study was conducted using the Pharmaceutical Benefits Scheme 10% sample of pharmacy claims data.People with ADwere defined as those dispensed medicines for dementia (cholinesterase inhibitors, memantine, or risperidone for behavioral and psychological sympto...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - Category: Drugs & Pharmacology Authors: Tags: Original Research Article Source Type: research
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