Characterization of the Therapeutic Profile of Albiflorin for the Metabolic Syndrome

Albiflorin (AF) is a small molecule (MW 481) isolated from Paeoniae radix, a plant used as a remedy for various conditions with pathogenesis shared by metabolic diseases. Reported here is our characterization of its therapeutic profiles in three mouse models with distinctive pathological features of metabolic syndrome (MetS). Our results firstly showed that AF alleviated high fat (HF) induced obesity and associated glucose intolerance, suggesting its therapeutic efficacy for MetS. In the type 2 diabetes (T2D) model induced by a combination of HF and low doses of streptozotocin, AF lowered hyperglycaemia and improved insulin-stimulated glucose disposal. In the non-alcoholic steatohepatitis-like model resulting from a HF and high cholesterol (HF-HC) diet, AF reversed the increased liver triglyceride and cholesterol, plasma aspartate aminotransferase, and liver TNFα mRNA levels. Consistent with its effect in promoting glucose disposal in HF-fed mice, AF stimulated glucose uptake and GLUT4 translocation to the plasma membrane in L6 myotubes. However, these effects were unlikely to be associated with activation of insulin, AMPK, ER, or cellular stress signalling cascades. Further studies revealed that AF increased the whole-body energy expenditure and physical activity. Taken together, our findings indicate that AF exerts a therapeutic potential for MetS and related diseases possibly by promoting physical activity associated whole-body energy expenditure and glucose uptake i...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
In this study, P contents and oxygen isotope composition of inorganic phosphate (δ18OP) of different pools (H2O-P, NaHCO3-P, NaOH-P, and HCl-P) in typical agricultural soil from Northeast China and Central China were analyzed and quantified. The results showed that fertilizer and land use were important factors influencing the contents of H2O-Pt and NaHCO3-Pt and the soil TP contents from different types of soils were greatly affected by soil weathering degree. The δ18OP of different P pools indicated that the difference in utilization extent of different P fractions by microorganisms and the δ18OP values...
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
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Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
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Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
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Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
Abstract The occurrence, air-sea exchange, and gas-particle partitioning of polybrominated diphenyl ethers (PBDEs) were analyzed during a 2015 research expedition from the East China Sea (ECS) to the open Northwest Pacific Ocean (NWP). The sum of 13 PBDEs (Σ13PBDEs) in air and surface seawater varied in the range of 0.54-14.5. pg m-3 and 0.60-13.5 pg L-1, respectively, with the highest concentrations observed in the ECS. The Clausius-Clapeyron approach and air mass origin analysis indicated that continued primary emissions of PBDEs, particularly BDE-209, from East Asian sources governed the spatial varia...
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
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Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
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Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
Publication date: Available online 16 November 2019Source: Advances in Space ResearchAuthor(s): Pengfei Zhang, Rui Tu, Wenjun Wu, Jinhai Liu, Xingxing Wang, Rui ZhangAbstractThe primary system of Chinese global BeiDou satellite system (BDS-3) was completed to provide global services on December 27, 2018; this was a key milestone in the development process for BDS in terms of its provision of global services. Therefore, this study analyzed the current performance of BDS-3, including its precise positioning, velocity estimation, and time transfer (PVT). The datasets were derived from international GNSS monitoring and assessm...
Source: Advances in Space Research - Category: Science Source Type: research
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Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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