Characterization of the Therapeutic Profile of Albiflorin for the Metabolic Syndrome

Albiflorin (AF) is a small molecule (MW 481) isolated from Paeoniae radix, a plant used as a remedy for various conditions with pathogenesis shared by metabolic diseases. Reported here is our characterization of its therapeutic profiles in three mouse models with distinctive pathological features of metabolic syndrome (MetS). Our results firstly showed that AF alleviated high fat (HF) induced obesity and associated glucose intolerance, suggesting its therapeutic efficacy for MetS. In the type 2 diabetes (T2D) model induced by a combination of HF and low doses of streptozotocin, AF lowered hyperglycaemia and improved insulin-stimulated glucose disposal. In the non-alcoholic steatohepatitis-like model resulting from a HF and high cholesterol (HF-HC) diet, AF reversed the increased liver triglyceride and cholesterol, plasma aspartate aminotransferase, and liver TNFα mRNA levels. Consistent with its effect in promoting glucose disposal in HF-fed mice, AF stimulated glucose uptake and GLUT4 translocation to the plasma membrane in L6 myotubes. However, these effects were unlikely to be associated with activation of insulin, AMPK, ER, or cellular stress signalling cascades. Further studies revealed that AF increased the whole-body energy expenditure and physical activity. Taken together, our findings indicate that AF exerts a therapeutic potential for MetS and related diseases possibly by promoting physical activity associated whole-body energy expenditure and glucose uptake i...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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Publication date: 5 February 2021Source: Journal of Molecular Structure, Volume 1225Author(s): Yuqing Wu, Rui Fausto
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB01561J, PaperKim E. Schlipk öter, Tobias Betke, Joscha Kleber, Harald Gröger, Andreas Liese Solvent-free and full atomic economic fatty alcohol synthesis in a two-step bio- and chemocatalytic reaction sequence. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
Publication date: Available online 24 September 2020Source: Saudi Journal of Biological SciencesAuthor(s): Nora A. AlFaris, Ghedeir M. Alshammari, Jozaa Z. AlTamimi, Lujain A. AlMousa, Nora M. AlKehayez, Dalal H. Aljabryn, Reham I. Alagal, Mohammed A. Yahya
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
Publication date: Available online 24 September 2020Source: Microvascular ResearchAuthor(s): Lauren Van Hove, Kirsten R. Kim, Denise M. Arrick, William G. Mayhan
Source: Microvascular Research - Category: Biochemistry Source Type: research
Publication date: Available online 24 September 2020Source: Chinese Journal of Chemical EngineeringAuthor(s): Yang Yu, Guiying Li, Wanqing Han, Linhua Zhu, Tian Si, Hong Wang, Yanlin Sun, Yanping He
Source: Chinese Journal of Chemical Engineering - Category: Chemistry Source Type: research
Authors: Clapp B, Liggett E, Ma C, Castro C, Montelongo S, Van Noy K, Dilday J, Tyroch A Abstract Background: Many bariatric surgeons test the anastomosis and staple lines with some sort of provocative test. This can take the form of an air leak test with a nasogastric tube with methylene blue dye or with an endoscopy. The State Department of Health Statistics in Texas tracks outcomes using the Texas Public Use Data File (PUDF). Methods: We queried the Texas Inpatient and Outpatient PUDFs for 2013 to 2017 to examine the number of bariatric surgeries with endoscopy performed at the same time. We used the Interna...
Source: JSLS : Journal of the Society of Laparoendoscopic Surgeons - Category: Surgery Tags: JSLS Source Type: research
Authors: Mishra VN, Kumari N, Pathak A, Chaturvedi RK, Gupta AK, Chaurasia RN Abstract An outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan City, China, in December 2019. Since then, the outbreak has grown into a global pandemic, and neither a vaccine nor a treatment for the disease, termed coronavirus disease 2019 (COVID-19), is currently available. The slow translational progress in the field of research suggests that a large number of studies are urgently required. In this context, this review explores the impact of bacteriophages on SARS-CoV-2, especially conce...
Source: International Journal of Microbiology - Category: Microbiology Tags: Int J Microbiol Source Type: research
Publication date: Available online 24 September 2020Source: Gene Expression PatternsAuthor(s): Ning Zhang, Zhongdian Dong, Wenteng Xu, Zhongkai Cui, Qian Wang, Songlin Chen
Source: Gene Expression Patterns - Category: Genetics & Stem Cells Source Type: research
Abstract Gynostemma yixingense, an important medicinal member of the Cucurbitaceae family, is an endemic herbaceous species distributed in East China. It is morphologically similar to the plants in the same genus, which resulted in some confusion in identification and application. Meanwhile, there are still some controversies in taxonomy. Herein, the complete chloroplast genome sequence of G. yixingense was obtained by Illumina paired-end sequencing technology and compared to other chloroplast genome sequences of congeneric species. The complete chloroplast genome of G. yixingense is 157,910 bp in length with 36.94% GC con...
Source: Genetics and Molecular Biology - Category: Genetics & Stem Cells Source Type: research
Ali Mahzari1, Songpei Li1, Xiu Zhou1,2, Dongli Li2, Sherouk Fouda1, Majid Alhomrani1, Wala Alzahrani1, Stephen R. Robinson1 and Ji-Ming Ye1,2* 1Lipid Biology and Metabolic Disease Laboratory, School of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia 2School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, China The present study investigated the effects of matrine on non-alcoholic steatohepatitis (NASH) in mice induced by a methionine choline-deficient (MCD) diet and the mechanism involved. The study was performed in C57B/6J mice fed a MCD diet for 6 weeks to induce NAS...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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