Learning from Antibodies: Phage Host-Range Engineering.

Learning from Antibodies: Phage Host-Range Engineering.
Cell Host Microbe. 2019 Oct 09;26(4):445-446
Authors: Russell J, Bikard D
Abstract
In a recent Cell paper, Yehl et al., 2019 find that bacteriophage T3 binds its host via four distal loops on the tail fiber. Randomization of these regions yield bacteriophage libraries capable of infecting resistant bacteria and preventing further resistance. These strategies may generate phage capable of infecting new hosts.
PMID: 31600495 [PubMed - in process]

Source: Cell Host and Microbe - October 8, 2019 Category: Microbiology Authors: Russell J, Bikard D Tags: Cell Host Microbe Source Type: research