Restitution and adaptation measurements for the estimate of short-term cardiac action potential memory: comparison of five human ventricular models

ConclusiondER, as we define it and together with other approaches described in the study, provides an univocal way to measure STM under extreme cardiac pacing conditions. Given the relevance of AP memory for repolarization dynamics and stability, STM should be considered, among other usual biomarkers, to validate and tune cardiac AP models. The possibility of extending the method to in vivo cellular and whole organ models can also be profitably explored.

Source: Europace - August 16, 2019 Category: Cardiology Source Type: research